Fludarabine Phosphate EP Impurity G CAS 548774-56-7
| CAS No. | 548774-56-7 |
| Molecular Formula | C10H12ClFN5O6P |
| Molecular Weight | 383.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fludarabine Phosphate EP Impurity G.
As a process- or degradation-related impurity, Fludarabine Phosphate EP Impurity G (CAS 548774-56-7, C10H12ClFN5O6P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fludarabine Phosphate EP Impurity G (C10H12ClFN5O6P) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Fludarabine Phosphate EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12ClFN5O6P |
| Molecular Weight | 383.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Fludarabine Standards
- Fludarabine Phosphate EP Impurity J (CAS CATO-C4X-184610)
- Fludarabine Phosphate EP Impurity F (CAS 159002-28-5)
- Fludarabine Phosphate Impurity 11 (CAS CATO-C4X-184611)
- Fludarabine Phosphate (CAS 75607-67-9)
- Fludarabine Phosphate Impurity 13 (CAS 71261-44-4)
- Fludarabine Phosphate Impurity 14 (CAS CATO-C4X-184614)
- Fludarabine Phosphate EP Impurity A (CAS 62314-92-5)
- Fludarabine Phosphate EP Impurity I (CAS 7561-54-8)
Recommended Standards
- Empagliflozin impurity 204 (CAS 1800196-43-3)
- IMD 0354 (CAS 978-62-1)
- 5-(2-Chlorophenyl)-1-[2,4-dichloro-5-(propan-2-yloxy)phenyl]-1H-1,2,3,4-tetrazole (CAS 338961-45-8)
- N-(3,4-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide (CAS 2244536-10-3)
- N-Nitroso Bilastine impurity 131 (CAS CATO-C4X-2253131)
- Aztreonam Dimer Impurity 36 (CAS CATO-C4X-152236)
- Dalbavancin Impurity 32 (CAS CATO-C4X-160232)
- 2-(3,5-Dimethoxyphenyl)-2-methylpropan-1-ol (CAS 1515519-30-8)
- 3-Chloro-N-propylbenzamide (CAS 35306-50-4)
- 7-Boc-4-chloro-5,6,7,8-tetrahydro-1,7-naphthyridine (CAS 1823232-54-7)
- Tosufloxacin impurity 6 (CAS CATO-C4X-19766)
- (4-(2-Aminoethyl)piperazin-1-yl)(cyclobutyl)methanone hydrochloride (CAS 1311317-95-9)
- 5-(4-Piperidinyl)oxazole (CAS 1211527-20-6)
- ((Cys31,Nva34)-Neuropeptide Y (27-36))2 (CAS 172997-92-1)
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