4-(Trifluoromethylsulfonyl)phenylisocyanate CAS 55226-16-9
| CAS No. | 55226-16-9 |
| Molecular Formula | C8H4F3NO3S |
| Molecular Weight | 251.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Trifluoromethylsulfonyl)phenylisocyanate (C8H4F3NO3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 4-(Trifluoromethylsulfonyl)phenylisocyanate (CAS 55226-16-9), a certified reference material (molecular formula C8H4F3NO3S, MW 251.18 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-(Trifluoromethylsulfonyl)phenylisocyanate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4F3NO3S |
| Molecular Weight | 251.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Trifluoromethylsulfonyl Standards
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- 1-Methyl-4-(trifluoromethylsulfonyl)benzene (CAS 383-10-8)
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Recommended Standards
- 2-Fluoro-N-methoxy-N-methyl-4-(trifluoromethyl)benzamide (CAS 198967-27-0)
- 4-Cyanophenyl trifluoromethanesulfonate (CAS 66107-32-2)
- 2-Fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)benzamide (CAS 680610-54-2)
- 5-(Sec-butyl)-4,6-dichloro-2-(methylthio)pyrimidine (CAS 944702-76-5)
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- 2-[(1-phenylethyl)amino]acetohydrazide (CAS 56720-93-5)
- 2-[(3-Chlorophenyl)methyl]-1,3-thiazole-4-carboxylic acid (CAS 1094423-38-7)
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- (S)-5-Oxotetrahydrofuran-3-carboxylic acid (CAS 4694-66-0)
- Sodium DL-2-Hydroxybutyrate (CAS 5094-24-6)
- 4-Bromo-2-methyl-6-(trifluoromethyl)quinoline (CAS 1070879-56-9)
- N-Acetylputrescine hydrochloride (CAS 18233-70-0)
- 1-(1H-1,2,3,4-tetrazol-5-yl)cyclopropan-1-amine (CAS 787545-18-0)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com