N-Nitroso Atropine EP Impurity B CAS 55855-45-3
| CAS No. | 55855-45-3 |
| Molecular Formula | C16H20N2O4 |
| Molecular Weight | 304.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C16H20N2O4, N-Nitroso Atropine EP Impurity B contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 304.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, N-Nitroso Atropine EP Impurity B (CAS 55855-45-3, C16H20N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), N-Nitroso Atropine EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H20N2O4 |
| Molecular Weight | 304.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Nitrogen Atoms | 2 |
Related N Standards
- {2-nitroso-1-[4-(trifluoromethoxy)phenyl]prop-1-en-1-yl}(propoxy)amine (CAS 1807938-69-7)
- N-nitroso-desmethyl-chlophedianol (CAS CATO-C4X-34121)
- N-Nitroso Ranolazine Impurity 15 (CAS CATO-C4X-102615)
- N-Nitroso Vilazodone Impurity 11 (CAS 2512217-82-0)
- N-Nitroso Desloratadine Impurity A (CAS CATO-C4X-143056)
- N-Nitroso Bupropion 3,4-Dichloro Impurity 63 (CAS CATO-C4X-120363)
- N-Nitroso Bupropion 3,5-Dichloro Impurity 64 (CAS CATO-C4X-120364)
- N-nitroso-desmethyl-carbinoxamine (CAS CATO-C4X-25613)
Recommended Standards
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- Ethyl 2-benzamido-2-cyanoacetate (CAS 55828-02-9)
- Loxoprofen Impurity 1 (CAS 96824-28-1)
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- Anamorelin Impurity 10 (CAS CATO-C4X-285910)
- 3-Iodo-2-(iodomethyl)prop-1-ene (CAS 17616-43-2)
- Des-Leu26-Tirzepatide (CAS CATO-CPTD788947)
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