Vinblastine Impurity 10 CAS 55855-88-4
| CAS No. | 55855-88-4 |
| Molecular Formula | C44H56N4O7 |
| Molecular Weight | 752.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Vinblastine Impurity 10 (CAS 55855-88-4, C44H56N4O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Vinblastine Impurity 10 (C44H56N4O7) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C44H56N4O7 |
| Molecular Weight | 752.94 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Nitrogen Atoms | 4 |
Related Vinblastine Standards
- Vinblastine impurity A (CAS CATO-C4X-19845)
- Vinblastine impurity 6 (CAS CATO-C4X-19846)
- Vinblastine impurity 7 (CAS CATO-C4X-19847)
- Vinblastine impurity 8 (CAS CATO-C4X-19848)
- 6b-Vinblastine (CAS 363623-08-9)
- VINBLASTINE SULFATE (CAS 1212440-53-3)
- Vinblastine-d3 Sulfate (CAS 1246818-72-3)
- Vinblastine Sulfate (CAS 143-67-9)
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