Trifluoro-methanesulfonic acid (1,1-dimethylethyl)bis(1-methylethyl)silyl ester CAS 561322-37-0
| CAS No. | 561322-37-0 |
| Molecular Formula | C11H23F3O3SSi |
| Molecular Weight | 320.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trifluoro-methanesulfonic acid (1,1-dimethylethyl)bis(1-methylethyl)silyl ester.
Trifluoro-methanesulfonic acid (1,1-dimethylethyl)bis(1-methylethyl)silyl ester (CAS 561322-37-0) is a high-purity analytical reference standard with the molecular formula C11H23F3O3SSi and a molecular weight of 320.44 g/mol.
The molecular framework of Trifluoro-methanesulfonic acid (1,1-dimethylethyl)bis(1-methylethyl)silyl ester (C11H23F3O3SSi) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H23F3O3SSi |
| Molecular Weight | 320.44 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | -1.0 |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
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Recommended Standards
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- Tetraphenylmethane (CAS 630-76-2)
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- S-p-Tolyl propanethioate (CAS 18241-63-9)
- Tert-butyl 3-cyano-1H-indazole-1-carboxylate (CAS 1337881-54-5)
- Methyl 2-((5-(3-chlorobenzo[b]thiophen-2-yl)-1,3,4-oxadiazol-2-yl)thio)acetate (CAS 433694-47-4)
- Fmoc-MeAsp-OtBu (CAS 2271413-88-6)
- Tert-butyl 5'-fluoro-2'-oxo-1',4'-dihydro-2'H-spiro[piperidine-4,3'-quinoline]-1-carboxylate (CAS 1402232-78-3)
- (2S)-2-[(2-Fluorophenyl)formamido]-3-methylbutanoic acid (CAS 956373-63-0)
- Salbutamol Impurity 172 (CAS 2691147-78-9（free base）)
- Galanin-Like Peptide (rat) trifluoroacetate salt (CAS 245114-97-0)
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