Ethyl 2-(2-chloro-2-phenylacetamido)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate CAS 565165-66-4
| CAS No. | 565165-66-4 |
| Molecular Formula | C20H22ClNO3S |
| Molecular Weight | 391.91 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ethyl 2-(2-chloro-2-phenylacetamido)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (C20H22ClNO3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Ethyl 2-(2-chloro-2-phenylacetamido)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (CAS 565165-66-4) is a high-purity analytical reference standard with the molecular formula C20H22ClNO3S and a molecular weight of 391.91 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H22ClNO3S |
| Molecular Weight | 391.91 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- 2-Chloro-n-[3-(4-ethoxybenzoyl)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]acetamide (CAS 792954-21-3)
- 2-(3-Chloro-4-methoxyphenyl)-1-(4-{[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]methyl}piperidin-1-yl)ethan-1-one (CAS 1775467-44-1)
- 8-Chloro-11-(1H-indol-3-yl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (CAS 946386-80-7)
- Ethyl 2-((2-(3-chloro-4-ethoxyphenyl)pyrazolo[1,5-a]pyrazin-4-yl)thio)acetate (CAS 1105240-36-5)
- (3E)-3-({1-[(2-chloro-1,3-thiazol-5-yl)methyl]-1H-indol-3-yl}methylidene)-2,3-dihydro-1H-indol-2-one (CAS 866131-60-4)
- 4-Chloro-N'-(1-(phenylsulfonyl)piperidin-4-ylidene)benzohydrazide (CAS 478248-20-3)
- N-(5-Chloro-3-(phenylsulfonyl)-1H-indol-2-yl)-2-(ethylamino)acetamide (CAS 918493-45-5)
- 479482-38-7 6-Chloro-4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1,2-dihydro-1lambda~6~-thieno[2,3-e][1,2]thiazine-3-carboxamide DTXSID50715839 (CAS 479482-38-7)
Recommended Standards
- Clethodim Sulfone (CAS 111031-17-5)
- (E)-{1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethylidene}amino N-cyclohexylcarbamate (CAS 477872-49-4)
- N-(4-(5-Chlorothiophen-2-yl)thiazol-2-yl)-1-(methylsulfonyl)pyrrolidine-2-carboxamide (CAS 1219145-14-8)
- (4-Chlorophenyl)(4-hydroxy-4-(((4-methoxyphenyl)thio)methyl)piperidin-1-yl)methanone (CAS 866143-81-9)
- (2-Bromophenyl)(3,4-dimethoxyphenyl)methanone (CAS 23346-79-4)
- 2-Chloro-3-nitrobenzoyl chloride (CAS 34128-16-0)
- 2-Amino-4-(4-chlorophenyl)-5,6-dimethylpyridine-3-carbonitrile (CAS 333394-03-9)
- N-(2,3,4-trimethoxybenzyl)cyclopentanamine (CAS 418788-93-9)
- 2-Chloro-n-(2-phenylethyl)-n-(thiophen-2-ylmethyl)acetamide (CAS 335251-02-0)
- 3-(3-Bromophenyl)-1-(4-methylpyridin-2-yl)pyrrolidine-2,5-dione (CAS 110592-47-7)
- 1-Bromo-4-(bromomethyl)-2,5-bis(trifluoromethyl)benzene (CAS 1805513-09-0)
- N-methyl-N-phenylbenzenesulfonamide (CAS 90-10-8)
- (S)-2-(4-(trifluoromethyl)phenyl)pyrrolidine (CAS 1217816-57-3)
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com