Minoxidil Impurity 8 CAS 56828-37-6
| CAS No. | 56828-37-6 |
| Molecular Formula | C9H15N5O2 |
| Molecular Weight | 225.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Minoxidil Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Minoxidil Impurity 8 (CAS 56828-37-6, C9H15N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Minoxidil Impurity 8 (C9H15N5O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 225.25 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C9H15N5O2 |
| Molecular Weight | 225.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Nitrogen Atoms | 5 |
Related Minoxidil Standards
- Minoxidil Impurity 49 (CAS CATO-C4X-170049)
- Minoxidil Impurity 51 (CAS CATO-C4X-170051)
- Minoxidil Impurity 62 (CAS CATO-C4X-170062)
- Minoxidil Impurity 25 (CAS 7148-63-2)
- Minoxidil-d10 (CAS 1020718-66-4)
- Minoxidil Impurity 69 (CAS CATO-C4X-170069)
- Minoxidil Impurity 71 (CAS CATO-C4X-170071)
- Minoxidil Impurity 72 (CAS CATO-C4X-170072)
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