4-((3,4-Dihydroxybenzylidene)amino)-3-(4-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione CAS 573975-64-1
| CAS No. | 573975-64-1 |
| Molecular Formula | C15H11FN4O2S |
| Molecular Weight | 330.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4-((3,4-Dihydroxybenzylidene)amino)-3-(4-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 573975-64-1) is a high-purity analytical reference standard with the molecular formula C15H11FN4O2S and a molecular weight of 330.34 g/mol.
The molecular framework of 4-((3,4-Dihydroxybenzylidene)amino)-3-(4-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione (C15H11FN4O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 4-((3,4-Dihydroxybenzylidene)amino)-3-(4-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11FN4O2S |
| Molecular Weight | 330.34 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Dihydroxybenzylidene Standards
- 4-((3,4-Dihydroxybenzylidene)amino)-3-(2-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 577789-70-9)
- 3-(2-(2,3-Dihydroxybenzylidene)-1-methylhydrazinyl)benzo[d]isothiazole 1,1-dioxide (CAS 591242-33-0)
- 4-((3,4-Dihydroxybenzylidene)amino)-3-(m-tolyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 478256-29-0)
- 4-((2,4-Dihydroxybenzylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 497920-24-8)
- 4-((3,4-Dihydroxybenzylidene)amino)-3-(pyridin-2-yl)-1H-1,2,4-triazole-5(4H)-thione (CAS 613248-43-4)
- (5E)-5-(3,4-Dihydroxybenzylidene)-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one (CAS 897340-70-4)
- 4-((3,4-Dihydroxybenzylidene)amino)-3-(3-ethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 497922-01-7)
- 2,3-Bis(3,4-dihydroxybenzylidene)succinic acid (CAS 132367-95-4)
Recommended Standards
- 4-(5,5-Dimethyl-1,3-dioxan-2-yl)-1-(2-(trifluoromethyl)phenyl)butan-1-one (CAS 898786-61-3)
- 3-[2-(4-Imidazol-1-yl-phenyl)-2-oxoeth-(Z)-ylidene]-3,4-dihydro-1H-quinoxalin-2-one (CAS 946384-09-4)
- 4-(5,5-Dimethyl-1,3-dioxan-2-yl)-1-(4-(trifluoromethyl)phenyl)butan-1-one (CAS 898786-65-7)
- 3-[(3-hydrazino-3-oxopropyl)thio]propanohydrazide (CAS 6292-68-8)
- Ethyl 2-((2-chlorobenzyl)thio)-7-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate (CAS 907971-32-8)
- 3-Amino-1-[3-(trifluoromethoxy)phenyl]pyrrolidin-2-one (CAS 192318-32-4)
- methyl 5-chloro-3-(chlorosulfonyl)-2-methoxybenzoate (CAS 932854-23-4)
- 2,4,5-Trimethyl-1-(pyridin-2-yl)-1H-pyrrole-3-carbaldehyde (CAS 1087611-23-1)
- (R)-N-(sec-Butyl)-3,6-diethylpyrazin-2-amine (CAS 622835-11-4)
- 2,2-Dichloro-1-(1H-pyrrol-2-yl)ethanone (CAS 50371-55-6)
- tert-Butyl 4-(2-chloro-6-methylpyrimidin-4-yl)-3-methylpiperazine-1-carboxylate (CAS 1261235-51-1)
- 2-((4-Ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide (CAS 577989-05-0)
- 3-Cyclopropyl-1-ethyl-5-nitro-1H-pyrazole (CAS 1170914-04-1)
- Tau Peptide (401-411)-Lys-Lys trifluoroacetate salt (CAS 2022956-59-6)
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