Erlotinib Impurity 38 CAS 574738-66-2
| CAS No. | 574738-66-2 |
| Molecular Formula | C13H19NO6 |
| Molecular Weight | 285.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Erlotinib Impurity 38 (C13H19NO6) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Erlotinib Impurity 38 (CAS 574738-66-2) is a certified pharmaceutical impurity reference standard with the molecular formula C13H19NO6 and a molecular weight of 285.29 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H19NO6 |
| Molecular Weight | 285.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 1 |
Related Erlotinib Standards
- Erlotinib Impurity 65 (CAS CATO-C4X-106965)
- Erlotinib Impurity 66 (CAS CATO-C4X-106966)
- Erlotinib impurity 129 (CAS CATO-C4X-1069129)
- Erlotinib Impurity 52 (CAS 236750-62-2)
- Erlotinib Impurity 28 (CAS CATO-C4X-106928)
- Erlotinib Impurity 29 (CAS CATO-C4X-106929)
- Erlotinib Impurity 20 (CAS 938185-06-9)
- Erlotinib Impurity 17 (CAS 1417161-98-8)
Recommended Standards
- Mirabegron Impurity 69 (CAS CATO-C4X-103269)
- Ketorolac EP Impurity D (CAS 1391053-45-4)
- 66635-85-6 S9B9E35WUX Anirolac Anirolac [USAN:INN] 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-(4-methoxybenzoyl)-, (+-)- Anirolaco [Spanish] Anirolacum [Latin] (+-)-5-p-Anisoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid RS 37326 Anirolaco Anirolacum UNII-S9B9E35WUX RS-37326 (CAS 66635-85-6)
- Ketorolac EP Impurity G (CAS 1391051-90-3)
- Midazolam Impurity 23 (CAS CATO-C4X-150923)
- Axitinib Impurity 64 (CAS CATO-C4X-107164)
- Lumateperone impurity 60 (CAS CATO-C4X-220160)
- Fluvoxamine EP Impurity F-D4 N-nitroso (CAS CATO-C4X-195151)
- 2-Pentanone (CAS 107-87-9)
- (1S,6R)-7,7-Dimethylbicyclo[4.1.0]hept-3-ene-3-carboxylic acid (CAS 498-12-4)
- Darunavir Impurity 18 (CAS 1932330-83-0)
- 1-(1,1-dioxo-1$l^{6}-thiolan-3-yl)imidazolidine-2,4,5-trione (CAS 40408-55-7)
- 4,5,6,7-Tetrahydro-1H-pyrazolo[3,4-c]pyridin-3(2H)-one Hydrochloride (CAS 1187830-91-6)
- T-Peptide (CAS 2022956-62-1)
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