1-(5-Fluoro-2-hydroxyphenyl)butan-1-one CAS 575-67-7
| CAS No. | 575-67-7 |
| Molecular Formula | C10H11FO2 |
| Molecular Weight | 182.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(5-Fluoro-2-hydroxyphenyl)butan-1-one.
1-(5-Fluoro-2-hydroxyphenyl)butan-1-one (CAS 575-67-7) is a high-purity analytical reference standard with the molecular formula C10H11FO2 and a molecular weight of 182.19 g/mol.
The molecular framework of 1-(5-Fluoro-2-hydroxyphenyl)butan-1-one (C10H11FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11FO2 |
| Molecular Weight | 182.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluoro Standards
- 2-(4-Fluoro-3,5-dimethylphenyl)acetic acid (CAS 1000544-58-0)
- 1-(5-Fluoro-2-methoxyphenyl)propan-2-one (CAS 1017082-10-8)
- 3-(3-Fluoro-5-methylphenyl)propanoic acid (CAS 1017779-56-4)
- 3-Fluoro-4-(propan-2-yloxy)benzaldehyde (CAS 1021231-72-0)
- 3-(3-fluoro-4-methoxyphenyl)propanal (CAS 1036396-31-2)
- 3-Fluoro-2-isopropoxybenzaldehyde (CAS 1037092-98-0)
- Ethyl 3-Fluoro-2-methylbenzoate (CAS 114312-57-1)
- 2-(3-Fluoro-4-methoxyphenyl)-2-methyloxirane (CAS 1189785-35-0)
Recommended Standards
- 1-(4-Fluoro-3-methylphenyl)-3-methylurea (CAS 294849-27-7)
- 1-(5-Fluoro-2-methoxyphenyl)propan-1-one (CAS 653-64-5)
- 1-(4-Fluoro-3-methoxyphenyl)propan-1-one (CAS 82846-20-6)
- 2-(2-Fluoro-5-methylphenyl)-1,3-dioxolane (CAS 773095-39-9)
- 1-(3-Bromo-4-fluorophenyl)imidazolidin-2-one (CAS 1566125-49-2)
- Benzyl ((1-((S)-2-amino-3-methylbutanoyl)piperidin-2-yl)methyl)(ethyl)carbamate (CAS 1354023-82-7)
- 2-((2-Cyano-3-methylbutan-2-yl)amino)-2-oxoethyl 3-(thiophene-2-carboxamido)benzoate (CAS 871554-62-0)
- 2-[(3-fluorophenyl)amino]ethan-1-ol (CAS 404-95-5)
- (R)-N-(pyrrolidin-3-ylmethyl)methanesulfonamide (CAS 1219831-56-7)
- 4-(P-tolyl)tetrahydro-2H-pyran-4-amine (CAS 1097780-82-9)
- Etrasimod Impurity 74 (CAS CATO-C4X-321474)
- 1-(4-Bromo-3-methylphenyl)-2-chloroethan-1-one (CAS 1482580-85-7)
- (S)-2-Chloromandelic acid (CAS 52950-19-3)
- Myristoyl Pentapeptide-4 (CAS 1392416-25-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com