1-Chloro-2,5-difluoro-4-nitrobenzene CAS 578-28-9
| CAS No. | 578-28-9 |
| Molecular Formula | C6H2ClF2NO2 |
| Molecular Weight | 193.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 1-Chloro-2,5-difluoro-4-nitrobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 1-Chloro-2,5-difluoro-4-nitrobenzene (CAS 578-28-9), a certified reference material (molecular formula C6H2ClF2NO2, MW 193.54 g/mol) for analytical method development and quality control.
Based on its molecular formula C6H2ClF2NO2, 1-Chloro-2,5-difluoro-4-nitrobenzene contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 193.54 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H2ClF2NO2 |
| Molecular Weight | 193.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-Chloro-2,4-difluoro-3-nitrobenzene (CAS 1151767-58-6)
- 5-Chloro-1,3-difluoro-2-nitrobenzene (CAS 136272-31-6)
- 1-Chloro-2,4-difluoro-5-nitrobenzene, 97% (CAS 1481-68-1)
- 1-Chloro-2,3-difluoro-4-nitrobenzene (CAS 169468-80-8)
- 5-Chloro-2,3-difluoronitrobenzene (CAS 169468-81-9)
- 2-Chloro-3,4-difluoronitrobenzene (CAS 169468-83-1)
- 1-Chloro-2,5-difluoro-3-nitrobenzene (CAS 1805029-24-6)
- 3-Chloro-4,5-difluoronitrobenzene (CAS 53780-44-2)
Recommended Standards
- 1-Chloro-3,5-Difluoro-2-Nitro-Benzene (CAS 36556-55-5)
- 2-Chloro-1,3-difluoro-4-nitrobenzene (CAS 3847-58-3)
- 2-Chloro-1,3-difluoro-5-nitrobenzene (CAS 3828-41-9)
- 2-Chloro-3,5-difluoronitrobenzene (CAS 36556-59-9)
- 2-Chloro-4-(trifluoromethoxy)benzonitrile (CAS 874482-94-7)
- 2-Chloro-6-fluoro-3-methylquinoxaline (CAS 98416-71-8)
- 1-Amino-5,6-dimethyl-1H-benzo[d]imidazole-2(3H)-thione (CAS 159414-96-7)
- (S)-Benzyl 1-(2-(((benzyloxy)carbonyl)amino)acetyl)pyrrolidine-2-carboxylate (CAS 57294-41-4)
- Carboprost Impurity 5 (CAS CATO-C4X-21035)
- 1-Bromo-2,3,5,6-tetrafluoro-4-methoxybenzene (CAS 1682-04-8)
- 2-((4-Fluorobenzyl)amino)-N-phenylacetamide (CAS 917749-72-5)
- N-(6-Amino-5-cyclopropoxypyridin-2-yl)methanesulfonamide (CAS 1243451-92-4)
- (4-Methoxy-6-methylpyrimidin-2-yl)methanamine (CAS 66131-76-8)
- Neuropeptide W-23 (rat) (CAS 383415-89-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com