Brotizolam impurity B CRS CAS 57801-97-5

Purity 97%+In StockPharmaceutical Standards
CAS No.57801-97-5
Molecular FormulaC14H8BrClN4S
Molecular Weight379.66 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

Brotizolam impurity B CRS CAS 57801-97-5 chemical structure

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

Brotizolam impurity B CRS (CAS 57801-97-5) is a high-purity analytical reference standard with the molecular formula C14H8BrClN4S and a molecular weight of 379.66 g/mol.

Brotizolam impurity B CRS (C14H8BrClN4S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC14H8BrClN4S
Molecular Weight379.66 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)12.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1973
Halogen ContentCl/Br-containing
Nitrogen Atoms4
Sulfur Atoms1

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