Imipramine EP Impurity A HCl CAS 58-28-6
| CAS No. | 58-28-6 |
| Molecular Formula | C18H22N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 302.85 g/mol gives Imipramine EP Impurity A HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Imipramine EP Impurity A HCl (CAS 58-28-6), a pharmacopoeial impurity reference standard (molecular formula C18H22N2HCl, MW 302.85 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Imipramine EP Impurity A HCl (C18H22N2HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 302.85 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Imipramine EP Impurity A HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22N2 HCl |
| Molecular Weight | 302.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Imipramine Standards
- Imipramine Pamoate (CAS 10075-24-8)
- Imipramine-D3 maleate (CAS 112898-42-7)
- Imipramine Hydrochloride (CAS 113-52-0)
- Imipramine N-Oxide (CAS 1215681-42-7)
- Imipramine N-β-D-Glucuronide (CAS 165602-94-8)
- Imipramine impurity C (CAS 2307-88-2)
- Imipramine EP Impurity B (CAS 303-54-8)
- Imipramine EP Impurity A (CAS 50-47-5)
Recommended Standards
- Trametinib impurity 9 (CAS 29632-74-4)
- Nikethamide Impurity 14 (CAS 77727-88-9)
- Iomeprol Impurity 7 (CAS CATO-C4X-18207)
- 5-(Furan-2-carbonyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one (CAS 866134-28-3)
- (+)-Huperzine A (CAS 130791-77-4)
- 2,4,5-Trimethyl-N-(prop-2-yn-1-yl)furan-3-carboxamide (CAS 1090932-34-5)
- 3-{[2-Chloro-4-(tert-pentyl)phenoxy]-methyl}piperidine hydrochloride (CAS 1220032-87-0)
- (Z)-1-Chloro-2-(3-chloro-2-(4-fluorophenyl)-prop-1-en-1-yl)benzene (CAS 133001-05-5)
- 3-(2,3-Difluorophenyl)-2,2-dimethylpropanoic acid (CAS 1343431-02-6)
- (Leu31,Pro3?)-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 132699-73-1)
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