Ethyl 5-chloro-6-hydroxynicotinate CAS 58236-73-0
| CAS No. | 58236-73-0 |
| Molecular Formula | C8H8ClNO3 |
| Molecular Weight | 201.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 201.61 g/mol gives Ethyl 5-chloro-6-hydroxynicotinate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ethyl 5-chloro-6-hydroxynicotinate (CAS 58236-73-0) is a high-purity analytical reference standard with the molecular formula C8H8ClNO3 and a molecular weight of 201.61 g/mol.
Structurally, Ethyl 5-chloro-6-hydroxynicotinate (C8H8ClNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 201.61 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8ClNO3 |
| Molecular Weight | 201.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
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Recommended Standards
- Ethyl 5-amino-2-chloropyrimidine-4-carboxylate (CAS 59950-50-4)
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- 6-Chloro-N-ethyl-3-nitropyridin-2-amine (CAS 33742-69-7)
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- 4-(Pyridin-4-yl)piperidin-4-ol (CAS 233261-75-1)
- rel-Methyl (2R,4R)-4-(5-isopropyl-2-methylphenoxy)-2-pyrrolidinecarboxylate (CAS 1217791-17-7)
- diethyl [1-{[(2-ethoxyethoxy)carbonyl]amino}-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phosphonate (CAS 340031-52-9)
- Methyl 3-amino-3-methylhexanoate (CAS 1500509-07-8)
- 2-(3-(Methylthio)propyl)isoindoline-1,3-dione (CAS 52096-79-4)
- Ethyl 1-[5-(2,4-difluorobenzenesulfonamido)pyridin-2-yl]-3,5-dimethyl-1H-pyrazole-4-carboxylate (CAS 956960-40-0)
- Des-Lys20(Side Chain)-Semaglutide (CAS CATO-C4X-2226280)
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