Fluticasone Impurity 111 CAS 785806-92-0
| CAS No. | 785806-92-0 |
| Molecular Formula | C21H26ClFO4S |
| Molecular Weight | 428.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 428.95 g/mol gives Fluticasone Impurity 111 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Fluticasone Impurity 111 (CAS 785806-92-0) is a certified pharmaceutical impurity reference standard with the molecular formula C21H26ClFO4S and a molecular weight of 428.95 g/mol.
The molecular framework of Fluticasone Impurity 111 (C21H26ClFO4S) is characterized by a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fluticasone Impurity 111 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H26ClFO4S |
| Molecular Weight | 428.95 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Impurity 112 (CAS CATO-C4X-1650112)
- Fluticasone Impurity 106 (CAS CATO-C4X-1650106)
- Fluticasone Impurity 101 (CAS CATO-C4X-1650101)
- Fluticasone Impurity 49 (CAS CATO-C4X-165049)
- Fluticasone Impurity 68 (CAS 1744-64-5)
- Fluticasone Furoate Impurity 2 (CAS 1355648-15-5)
- Fluticasone Impurity 54 (CAS 4571-51-1)
- Fluticasone Impurity 96 (CAS CATO-C4X-165096)
Recommended Standards
- 4-(4-tert-Butylphenyl)-2-[4-(3-chlorophenyl)piperazin-1-yl]-4-oxobutanoic acid (CAS 301194-14-9)
- 2-Chloro-5,9,9-triphenyl-9H-fluorene (CAS 2356109-78-7)
- 2-((5-(4-Chlorophenyl)-1H-imidazol-2-yl)thio)-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)acetamide (CAS 337354-66-2)
- 2,2'-(4,6-Dichloro-5-methoxy-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 1221589-79-2)
- Atrasentan Impurity 30 (CAS 1058393-07-9)
- Oseltamivir impurity 292 (CAS 1402431-91-7)
- Edoxaban Impurity 112 (CAS CATO-C4X-1063112)
- (3-Aminoazetidin-1-yl)(3,5-dimethylisoxazol-4-yl)methanone (CAS 1484332-59-3)
- (R)-1-(3,5-Dichloropyridin-4-yl)ethanol, 97% (CAS 1254473-68-1)
- 2,5-Bis(benzyloxy)benzaldehyde (CAS 6109-54-2)
- N-(2,2,4-trimethyl-2,3-dihydrobenzofuran-7-yl)pyrazin-2-amine (CAS 866157-42-8)
- Sarpogrelate Impurity 17 (CAS 1659311-40-6)
- (2,5-Difluorophenyl)methanol (CAS 75853-20-2)
- Liraglutide (13-21) TFA Salt (CAS CATO-C4X-19928)
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