Vortioxetine Impurity 82 CAS 583-55-1
| CAS No. | 583-55-1 |
| Molecular Formula | C6H4BrI |
| Molecular Weight | 282.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Vortioxetine Impurity 82 (CAS 583-55-1, C6H4BrI) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to bromine/iodine substitution, an aromatic ring system, Vortioxetine Impurity 82 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 282.90 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C6H4BrI |
| Molecular Weight | 282.90 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br/I-containing |
Related Vortioxetine Standards
- Vortioxetine Impurity N1 (CAS CATO-C1202544)
- Vortioxetine Impurity 1 (CAS 1293342-91-2)
- Vortioxetine Impurity 3 (CAS 508233-82-7)
- Vortioxetine Impurity 3 (CAS 508234-03-5)
- Vortioxetine Impurity 34 (CAS 1293489-71-0)
- Vortioxetine Impurity 8 (CAS 13616-83-6)
- Vortioxetine Impurity 3 (CAS 960203-41-2)
- Vortioxetine Impurity 122 (CAS 2831955-36-1)
Recommended Standards
- 3-Bromoiodobenzene (CAS 591-18-4)
- 4-Bromoiodobenzene (CAS 589-87-7)
- 1-Bromo-4-iodobenzene-13C6 (CAS 1261170-84-6)
- 3,5-Dibromo-6-methoxy-2-aminopyrazine (CAS 1427500-63-7)
- Vonoprazan Impurity 103 (CAS CATO-C4X-1020103)
- Ferulic Acid Impurity N3 (CAS 155401-23-3)
- Pemafibrate Impurity 19 (CAS CATO-C4X-290319)
- (3R)-3-Methylmorpholine-3-carboxylic acid (CAS 1638744-32-7)
- 1-(2-Hydroxyethyl)-3-methyl-1H-pyrazole-4-carbaldehyde (CAS 1177321-94-6)
- Etacrynic Acid EP Impurity B (CAS 27929-18-6)
- 4-Cyclobutylpyridin-3-amine (CAS 1374665-67-4)
- 5-(4-Pentylcyclohexyl)-4-phenyl-4H-1,2,4-triazole-3-thiol (CAS 866039-81-8)
- C22 Dihydroceramide (CAS 147492-65-7)
- Tirzepatide Impurity 49 (CAS CATO-C4X-324049)
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