Nalmefene HCl CAS 58895-64-0
| CAS No. | 58895-64-0 |
| Molecular Formula | C21H25NO3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nalmefene HCl is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Nalmefene HCl (CAS 58895-64-0), molecular formula C21H25NO3HCl and molecular weight 375.89 g/mol, is a CATO reference standard with documented purity and traceability.
Nalmefene HCl (C21H25NO3HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25NO3 HCl |
| Molecular Weight | 375.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Nalmefene Standards
- Nalmefene-3-Glucuronide (CAS 113346-47-7)
- Nalmefene Hydrochloride (CAS 1228646-72-7)
- Nalmefene methiodide (CAS 136440-71-6)
- Nalmefene Impurity 10 (CAS 144265-45-2)
- Nalmefene Impurity 12 (CAS 176220-84-1)
- Nalmefene Impurity 14 (CAS 19493-09-5)
- Nalmefene Impurity 1 (CAS 42971-33-5)
- Nalmefene (CAS 55096-26-9)
Recommended Standards
- (4-hydroxybenzyl)triphenylphosphonium (CAS 1607833-66-8)
- 5-(Bromomethyl)-5'-methyl-2,2'-bipyridine (CAS 117585-58-7)
- 2-(Chloromethyl)-5-nitro-1,3-benzoxazole (CAS 119198-10-6)
- 2-(((3-Bromoimidazo[1,2-a]pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole (CAS 306280-26-2)
- N,N-Dimethyl-N’-(pyridin-2-yl)ethane-1,2-diamine (CAS 23826-72-4)
- 6-Methyl-3-(3-(trifluoromethyl)phenyl)-1,2,4-triazin-5(2H)-one (CAS 339102-74-8)
- trans-4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid (CAS 69907-67-1)
- 5,6-Dibromo-1,3-dimethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (CAS 24786-53-6)
- 5-((2-Chlorophenyl)sulfonyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (CAS 1255783-99-3)
- Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 2022956-56-3)
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