3-Nitroisonicotinoyl chloride CAS 59290-83-4
| CAS No. | 59290-83-4 |
| Molecular Formula | C6H3ClN2O3 |
| Molecular Weight | 186.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Nitroisonicotinoyl chloride.
3-Nitroisonicotinoyl chloride (CAS 59290-83-4), molecular formula C6H3ClN2O3 and molecular weight 186.55 g/mol, is a CATO reference standard with documented purity and traceability.
3-Nitroisonicotinoyl chloride (C6H3ClN2O3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3ClN2O3 |
| Molecular Weight | 186.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- 2-Chloro-5-nitroisonicotinaldehyde (CAS 946136-72-7)
- 5-Nitropyridine-2-carbonyl chloride (CAS 59290-88-9)
- 3-CHLORO-5-NITROPICOLINALDEHYDE (CAS 141238-22-4)
- 6-Nitronicotinoyl chloride (CAS 60780-82-7)
- 4-(Methoxycarbonyl)thiophene-3-carboxylic acid (CAS 4282-30-8)
- Oxcarbazepine (CAS 28721-07-5)
- 5-Amino-2-bromonicotinamide (CAS 1706438-59-6)
- 2-Hydroxypyrene-1-carbaldehyde (CAS 96918-22-8)
- 2-((Tert-butoxycarbonyl)amino)-3-(3,4,5-trifluorophenyl)propanoic acid (CAS 870483-32-2)
- 2-(cyclopropylamino)propanenitrile hydrochloride (CAS 1955507-41-1)
- 5-Propargylamino-dCTP (CAS 115899-39-3)
- decahydroquinoxalin-2-one (CAS 32044-23-8)
- Droperidol EP Impurity B HCl (CAS 1026015-45-1 (free base))
- Tirzepatide Impurity 38 (CAS CATO-C4X-324038)
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