8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide Midazolam 2,5-Dioxide (1.0mg/ml in Acetonitrile) CAS 59468-87-0
| CAS No. | 59468-87-0 |
| Molecular Formula | C18H13ClFN3O2 |
| Molecular Weight | 357.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 357.77 g/mol gives 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide Midazolam 2,5-Dioxide (1.0mg/ml in Acetonitrile) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide Midazolam 2,5-Dioxide (1.0mg/ml in Acetonitrile) (CAS 59468-87-0), molecular formula C18H13ClFN3O2 and molecular weight 357.77 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C18H13ClFN3O2, 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide Midazolam 2,5-Dioxide (1.0mg/ml in Acetonitrile) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 357.77 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-Dioxide Midazolam 2,5-Dioxide (1.0mg/ml in Acetonitrile) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13ClFN3O2 |
| Molecular Weight | 357.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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- 1-(3-Chloro-5-trifluoromethyl-pyridin-2-ylmethyl)-4-methanesulfonyl-piperazine (CAS 1311278-12-2)
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- 4-Chloro-3-{[2-(4-fluorophenyl)ethyl]sulfamoyl}benzoic acid (CAS 721414-47-7)
- 4-Chloro-6-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)pyrimidin-2-amine (CAS 2183593-91-9)
- 5-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)thiophene-2-sulfonic acid (CAS 339010-79-6)
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Recommended Standards
- 1',4-Dihydroxy Midazolam (1.0mg/ml in Acetonitrile) (CAS 64740-68-7)
- Cinolazepam (CAS 75696-02-5)
- Midazolam Impurity 35 (CAS CATO-C4X-150935)
- 7-(Chlorodifluoromethyl)-5-methyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine (CAS 866049-88-9)
- 9-Bromo-10b-isopropyl-5,6-dihydro-2H-oxazolo[2,3-a]isoquinoline-2,3(10bH)-dione (CAS 1951440-92-8)
- 4-[(2,5-Dimethyl-furan-3-carbonyl)-amino]-benzoic acid (CAS 309266-73-7)
- (3-Bromo-5-methylphenyl)(5-isopropyl-2,6-dimethoxypyrimidin-4-yl)methanone (CAS 1006300-02-2)
- (S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-([1,1'-biphenyl]-4-ylmethyl)propanoic acid (CAS 1260592-93-5)
- 1-(3,5-Dichlorophenyl)cyclobutanecarboxylic Acid (CAS 1260664-54-7)
- N-(3-acetylphenyl)-3-phenylpropanamide (CAS 316146-18-6)
- β-Hydroxyisovalerylshikonin (CAS 7415-78-3)
- 3-Chloro-2-({4-[(4-chlorophenyl)methoxy]phenyl}methyl)-5-(trifluoromethyl)pyridine (CAS 338410-49-4)
- 2-amino-2,5-dihydro-1,5,2-diazaphosphinin-6(1H)-one 2-oxide (CAS 69907-44-4)
- (Tyr?)-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 142878-79-3)
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