Midazolam 2-Oxide CAS 59468-86-9
| CAS No. | 59468-86-9 |
| Molecular Formula | C18H28ClFN3O |
| Molecular Weight | 356.89 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Midazolam 2-Oxide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Midazolam 2-Oxide (CAS 59468-86-9), molecular formula C18H28ClFN3O and molecular weight 356.89 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C18H28ClFN3O, Midazolam 2-Oxide contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 356.89 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Midazolam 2-Oxide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H28ClFN3O |
| Molecular Weight | 356.89 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam Impurity 35 (CAS CATO-C4X-150935)
- Midazolam Impurity 20 (CAS 151921-06-1)
- Midazolam Impurity 18 (CAS CATO-C4X-150918)
- Midazolam Impurity 19 (CAS CATO-C4X-150919)
- Midazolam Hydrochloride (CAS 59467-96-8)
- Midazolam 2,5-Dioxide-d6 (CAS 1215321-98-4)
- Midazolam Impurity 13 (CAS CATO-C4X-150913)
- Midazolam EP Impurity I (CAS 112811-67-3)
Recommended Standards
- 6-Chloro-4-{[(4-methylphenyl)methyl]sulfanyl}-8-thia-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(13),2(7),3,5,9,11-hexaene (CAS 478029-85-5)
- 1,3-Dichloro-2-iodo-5-(trifluoromethoxy)benzene (CAS 1414870-80-6)
- 5-Chloro-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide (CAS 746609-35-8)
- Mequitazine Impurity 2 (CAS 144827-81-6)
- 1,4-Benzenediol, 2-(1,1-dimethylethyl)-, polymer with diethenylbenzene, 4-(1,1-dimethylethyl)phenol, 4-methoxyphenol, 4,4'-(1-methylethylidene)bis[phenol] and 4-methylphenol (CAS 60837-57-2)
- N1,N1,N4,N4-Tetra(pyridin-4-yl)benzene-1,4-diamine (CAS 1218812-56-6)
- ((S)-1-Carboxy-2-(1-(3,5-dichlorobenzyl)-1H-imidazol-5-yl)ethyl)-L-leucine (CAS 305335-31-3)
- (3-Iodo-4-nitrophenyl)methanamine (CAS 1261747-83-4)
- 3-Oxotetrahydropyridazine-1(2H)-carbonyl chloride (CAS 54945-01-6)
- Ethyl 1-(3,4-dichlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylate (CAS 379239-10-8)
- Eszopiclone-d8 (CAS 1093385-24-0)
- 3-Cyano-5-methyl-1H-pyrazole-4-carboxylic acid (CAS 191419-06-4)
- (S)-2-((5-Methylisoxazol-3-yl)amino)propanoic acid (CAS 100960-41-6)
- Pancreatic Polypeptide (31-36), amide, human (CAS 74012-13-8)
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