N-(5-Chloropyridin-2-yl)tetrahydrofuran-2-carboxamide CAS 600159-40-8
| CAS No. | 600159-40-8 |
| Molecular Formula | C10H11ClN2O2 |
| Molecular Weight | 226.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(5-Chloropyridin-2-yl)tetrahydrofuran-2-carboxamide.
CATO supplies N-(5-Chloropyridin-2-yl)tetrahydrofuran-2-carboxamide (CAS 600159-40-8), a certified reference material (molecular formula C10H11ClN2O2, MW 226.66 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, N-(5-Chloropyridin-2-yl)tetrahydrofuran-2-carboxamide is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 226.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11ClN2O2 |
| Molecular Weight | 226.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- (6-Chloropyridin-3-yl)(3-hydroxypyrrolidin-1-yl)methanone (CAS 1342639-50-2)
- (S)-(2-chloropyridin-4-yl)(3-hydroxypyrrolidin-1-yl)methanone (CAS 1353994-77-0)
- (S)-(2-chloropyridin-3-yl)(3-hydroxypyrrolidin-1-yl)methanone (CAS 1353995-23-9)
- (2-Chloropyridin-3-yl)(morpholino)methanone (CAS 53062-98-9)
- 4-[(6-Chloropyridin-2-yl)carbonyl]morpholine (CAS 720693-08-3)
- N-(3-chloropyridin-2-yl)tetrahydrofuran-2-carboxamide (CAS 420089-58-3)
- 5-(6-Chloropyridin-3-yl)-4-methyl-4H-1,2,4-triazole-3-thiol (CAS 306936-79-8)
- 2-(((6-Chloropyridin-3-yl)methyl)(cyclopropyl)amino)ethanol (CAS 1308047-55-3)
Recommended Standards
- N-(4-Acetylaminophenyl)-2-chloroacetamide (CAS 2653-10-3)
- N,N'-(2-Chloro-1,4-phenylene)diacetamide (CAS 50610-32-7)
- Ticagrelor Impurity 100 (CAS 39856-08-1)
- n'-(2-Chloropropanoyl)benzohydrazide (CAS 851115-98-5)
- 3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-5-amine (CAS 72411-53-1)
- 3-Chloro-2-(3,4-difluorophenoxy)aniline (CAS 946682-44-6)
- Methyl (S)-2-amino-4,4,4-trifluorobutanoate (CAS 1016317-46-6)
- (S)-4-((tert-Butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-ol (CAS 2248638-09-5)
- Lamivudine Impurity B((2R,5R)-Isomer) (CAS 139757-68-9)
- N-((4-Hydroxytetrahydro-2H-pyran-4-yl)methyl)-2-(naphthalen-1-yl)acetamide (CAS 1351615-84-3)
- (2,5-Dimethyl-4-(trimethylsilyl)phenyl)boronic acid (CAS 1059575-28-8)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,4-dichlorophenyl)propanoic acid (CAS 352351-62-3)
- tert-Butyl 4-(phenoxymethyl)piperidine-1-carboxylate (CAS 405272-71-1)
- Semaglutide impurity 250 (CAS CATO-C4X-2226250)
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