Lamivudine Impurity B((2R,5R)-Isomer) CAS 139757-68-9
| CAS No. | 139757-68-9 |
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Lamivudine Impurity B((2R,5R)-Isomer) (CAS 139757-68-9), a pharmacopoeial impurity reference standard (molecular formula C8H11N3O3S, MW 229.26 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lamivudine Impurity B((2R,5R)-Isomer) (C8H11N3O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Lamivudine Impurity B((2R,5R)-Isomer) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lamivudine Standards
- Lamivudine Impurity B (CAS 141434-39-1)
- Lamivudine (CAS 134678-17-4)
- Lamivudine Impurity 24 (CAS CATO-C4X-119424)
- Lamivudine EP Impurity B ((2S,5S)-Isomer) (CAS 136846-20-3)
- Lamivudine EP Impurity D (Ent-Lamivudine) (CAS 134680-32-3)
- Lamivudine Impurity J (CAS 131086-26-5)
- Lamivudine EP Impurity J (CAS 145986-07-8)
- Lamivudine Impurity 19 (CAS 953806-67-2)
Recommended Standards
- Ticagrelor Impurity 62 (CAS CATO-C4X-109362)
- N-Phenyl-[1,2,5]thiadiazolo[3,4-d]pyrimidin-7-amine (CAS 6306-88-3)
- N4,N4-Dimethyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine (CAS 52222-39-6)
- Ceftazidime Impurity 88 (CAS CATO-C4X-121288)
- Methylnaltrexone Bromide Impurity 13 (CAS CATO-C4X-152113)
- Tranexamic Acid Impurity 6 (CAS CATO-C4X-17716)
- Dasatinib impurity 61 (CAS CATO-C4X-160761)
- 2-Fluoro-5-methylaniline (CAS 452-84-6)
- Finerenone Impurity 57 (CAS CATO-C4X-288057)
- (4aS,4bR,6S,6aS,7R,10aS,10bR,12aS)-7,8-Diformyl-1,1,4a,6a,10b-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,10,10a,10b,11,12,12a-hexadecahydrochrysen-6-yl acetate (CAS 53527-28-9)
- 4-Ethyl-6-methyl-1h,6h-[1,2]diazolo[3,4-c]pyrazol-3-amine (CAS 1311318-15-6)
- 8-fluoro-5H-[1,2,4]triazino[5,6-b]indole-3-thiol (CAS 75565-00-3)
- 9H-3,9-Bicarbazole (CAS 18628-07-4)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
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