Etomidate Impurity 10 CAS 60197-34-4

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.60197-34-4
Molecular FormulaC11H12N2
Molecular Weight172.23 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Etomidate Impurity 10 CAS 60197-34-4 chemical structure

Description

As a process- or degradation-related impurity, Etomidate Impurity 10 (CAS 60197-34-4, C11H12N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, Etomidate Impurity 10 is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 172.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC11H12N2
Molecular Weight172.23 g/mol
Purity>90%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)7.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1974
Nitrogen Atoms2

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