Etomidate Impurity 1 CAS 844658-92-0
| CAS No. | 844658-92-0 |
| Molecular Formula | C11H12N2 |
| Molecular Weight | 172.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Etomidate Impurity 1.
CATO supplies Etomidate Impurity 1 (CAS 844658-92-0), a pharmacopoeial impurity reference standard (molecular formula C11H12N2, MW 172.23 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Etomidate Impurity 1 (C11H12N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12N2 |
| Molecular Weight | 172.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Etomidate Standards
- Etomidate Impurity 10 (CAS 60197-34-4)
- Etomidate Impurity 12 (CAS 36065-27-7)
- Etomidate Impurity 33 (CAS 6284-14-6)
- Etomidate Impurity 24 (CAS 91284-61-6)
- Etomidate Impurity 19（Mixture of Tautomers） (CAS CATO-C4X-188419)
- Etomidate Impurity N3 (CAS 31502-34-8)
- Etomidate impurity 64 (CAS 36293-00-2)
- Etomidate impurity 69 (CAS CATO-C4X-188469)
Recommended Standards
- DL-Phenyl-d5-alanine-3,3-d2 (CAS 74228-83-4)
- N,1-Dimethylisoquinolin-5-amine (CAS 53760-81-9)
- 8-ethylquinolin-4-amine (CAS 948293-65-0)
- N,N-Dimethylisoquinolin-1-amine (CAS 23724-92-7)
- Edoxaban Impurity 98 (p-Toluenesulfonic acid) (CAS CATO-C4X-106398)
- Ozagrel Impurity 8 (CAS 141286-90-0)
- Promethazine Impurity 22 (CAS CATO-C4X-141822)
- Methyl 1-(2-formyl-5-(trifluoromethyl)phenyl)piperidine-4-carboxylate (CAS 1835265-61-6)
- 2-Hydroxy-N,3-dimethylbenzamide (CAS 1019466-95-5)
- Ethyl 2-Propyloxazole-4-carboxylate (CAS 36190-02-0)
- 2-((Dimethylamino)methyl)-4-methoxybenzaldehyde hydrochloride (CAS 1417569-70-0)
- 1-(2-((3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea (CAS 1797181-12-4)
- 2-Chloro-1-[2,5-dimethyl-1-(3-methylphenyl)-1h-pyrrol-3-yl]ethan-1-one (CAS 610274-30-1)
- Neuropeptide Y, porcine (CAS 82785-45-3)
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