Nifedipine HCl CAS 60299-11-8
| CAS No. | 60299-11-8 |
| Molecular Formula | C17H18N2O6 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nifedipine HCl is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Nifedipine HCl (CAS 60299-11-8), a certified reference material (molecular formula C17H18N2O6HCl, MW 382.80 g/mol) for analytical method development and quality control.
Nifedipine HCl (C17H18N2O6HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18N2O6 HCl |
| Molecular Weight | 382.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Nifedipine Standards
- Nifedipine Impurity 14 (CAS 108139-78-2)
- Nifedipine EP Impurity C (E-Isomer) (CAS 111304-29-1)
- Nifedipine EP Impurity C (Z-Isomer) (CAS 111304-31-5)
- Nifedipine Impurity 10 (CAS 114709-68-1)
- Nifedipine-d6 (CAS 1188266-14-9)
- Nifedipine-d4 (2-nitrophenyl-d4) (CAS 1219798-99-8)
- Nifedipine impurity 39 (CAS 128001-11-6)
- Nifedipine EP Impurity D (CAS 14205-39-1)
Recommended Standards
- 1-(2-(2-(2-Chloropyridin-4-yl)ethyl)piperidin-1-yl)ethan-1-one (CAS 1316221-46-1)
- (r)-2-Amino-2-(3,4-dimethylphenyl)ethan-1-ol (CAS 1213493-10-7)
- 4-Fluoro-5-iodoindolin-2-one (CAS 2090335-37-6)
- N,N-Dimethyl-1-piperazineacetamide (CAS 39890-43-2)
- Copper Oxychloride (CAS 1332-40-7)
- 1-(2-Chloro-5-(trifluoromethyl)pyridin-3-yl)ethan-1-one (CAS 944904-73-8)
- 3-Methyl-2-thienylzinc bromide 0.5 M in Tetrahydrofuran (CAS 312693-45-1)
- 1-(9H,9'H-[9,9'-Bifluoren]-2-yl)ethanone (CAS 90020-78-3)
- 3-(6-((4-Methylquinolin-2-yl)oxy)hexyl)thiazolidine dihydrochloride (CAS 41288-25-9)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
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