Nifedipine EP Impurity C (E-Isomer) CAS 111304-29-1
| CAS No. | 111304-29-1 |
| Molecular Formula | C12H11NO5 |
| Molecular Weight | 249.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nifedipine EP Impurity C (E-Isomer) (C12H11NO5) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Nifedipine EP Impurity C (E-Isomer) (CAS 111304-29-1, C12H11NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nifedipine EP Impurity C (E-Isomer) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11NO5 |
| Molecular Weight | 249.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 1 |
Related Nifedipine Standards
- Nifedipine EP Impurity C (Z-Isomer) (CAS 111304-31-5)
- Nifedipine EP Impurity C (CAS 39562-27-1)
- Nifedipine Impurity 22 (CAS CATO-C4X-141022)
- Nifedipine Impurity 35 (CAS CATO-C4X-141035)
- Nifedipine Impurity 40 (CAS 464917-82-6)
- Nifedipine Impurity 36 (CAS CATO-C4X-141036)
- Nifedipine Impurity 23 (CAS 65962-15-4)
- Nifedipine Impurity 34 (CAS 89088-71-1)
Recommended Standards
- 6,8-Dimethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 111185-88-7)
- (2Z)-3-{[2-(Methoxycarbonyl)phenyl]carbamoyl}prop-2-enoic Acid (CAS 112881-73-9)
- Benzyl (2,5-dioxoimidazolidin-4-yl)carbamate (CAS 111140-90-0)
- Propanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-2-methyl- (CAS 115761-50-7)
- Iodixanol EP Impurity I (CAS CATO-C4X-16639)
- Diltiazem Impurity N2 (CAS 42399-50-8)
- Pinaverium Bromide Impurity 44 (CAS 87325-77-7)
- 4-(3-Acetyl-2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid (CAS 870540-39-9)
- n-Methyl-3-(2-methylthiazol-4-yl)aniline (CAS 1339729-30-4)
- Tert-butyl 2-(2-ethoxy-2-oxoethyl)-3-oxopyrrolidine-1-carboxylate (CAS 1279815-78-9)
- N-[3-(2-Phenoxyethoxy)benzyl]-1-hexadecanamine (CAS 1040686-70-1)
- 1-Oxa-3-azaspiro[4.4]nonane-2,4-dione (CAS 67852-27-1)
- Oxaliplatin (CAS 61825-94-3)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
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