Galantamine EP Impurity F (ent-Galantamine) CAS 60384-53-4
| CAS No. | 60384-53-4 |
| Molecular Formula | C17H21NO3 |
| Molecular Weight | 287.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 287.35 g/mol gives Galantamine EP Impurity F (ent-Galantamine) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Galantamine EP Impurity F (ent-Galantamine) (CAS 60384-53-4, C17H21NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Galantamine EP Impurity F (ent-Galantamine) (C17H21NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H21NO3 |
| Molecular Weight | 287.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Nitrogen Atoms | 1 |
Related Galantamine Standards
- Galantamine Impurity 11 (CAS 21041-10-1)
- Galantamine EP Impurity B (CAS 1668-85-5)
- Galantamine EP Impurity A (Galantaminone) (CAS 510-77-0)
- Galantamine EP Impurity C (CAS 21133-52-8)
- Galantamine-d6 (CAS 1128109-00-1)
- Galantamine EP Impurity E (N-Desmethyl Galanthamine) (CAS 41303-74-6)
- Galantamine Impurity 6 (CAS 60755-80-8)
- Epi-Galantamine N-Oxide (CAS 366485-18-9)
Recommended Standards
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- Ketoprofen Impurity 47 (CAS 620-86-0)
- Fluoxetine Impurity 24 (CAS CATO-C4X-135224)
- 3-Oxo-3,4-dihydroquinoxaline-2-carbonitrile (CAS 34731-47-0)
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- Potassium Peroxymonosulfate Sulfate (CAS 37222-66-5)
- 2-(Ethylthio)-1-(o-tolyl)-5-(p-tolyl)-1H-imidazole (CAS 1207026-70-7)
- N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidin-2-yl)-2,2-diMethyl propanaMide (CAS 149765-16-2)
- 2-Isobutoxy-4-nitrobenzoic acid, 97% (CAS 766552-33-4)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
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