Nicotinamide Impurity 2 CAS 606-68-8
| CAS No. | 606-68-8 |
| Molecular Formula | C21H27N7O14P2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 686.42 g/mol gives Nicotinamide Impurity 2 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nicotinamide Impurity 2 (CAS 606-68-8, C21H27N7O14P2Na) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, Nicotinamide Impurity 2 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 686.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nicotinamide Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H27N7O14P2 2*Na |
| Molecular Weight | 686.42 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 7 |
Related Nicotinamide Standards
- beta-Nicotinamide adenine dinucleotide, reduced dipotassium salt (CAS 104809-32-7)
- Nicotinamide hypoxanthine dinucleotide sodium salt (CAS 104809-38-3)
- α-Nicotinamide adenine dinucleotide, reduced disodium salt (CAS 108321-31-9)
- Nicotinamide-amide-<SUP>15</SUP>N (CAS 113950-01-9)
- Nicotinamide Impurity 7 (CAS 114-33-0)
- Nicotinamide-d4 N-Oxide_x0000_ (d4 Major) (CAS 1246817-64-0)
- Nicotinamide Riboside (CAS 1341-23-7)
- Nicotinamide EP Impurity C (CAS 1452-77-3)
Recommended Standards
- Ceftizoxime Impurity 54 (CAS CATO-C4X-179354)
- Ketorolac Impurity 79 (CAS CATO-C4X-166979)
- Tenofovir Disoproxil USP Related Compound A (CAS 1432630-26-6)
- 5,6-Dibromo-2,3-dihydro-isoindol-1-one (CAS 954239-43-1)
- 5-tert-Butylisophthalic acid (CAS 2359-09-3)
- 2-Amino-3-(3-chloro-4-methoxyphenyl)propanoic acid (CAS 603105-74-4)
- 2-(2-(1,3-Dioxolan-2-yl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1073354-07-0)
- 2-Bromo-1-(2,5-dimethylthiophen-3-yl)ethan-1-one (CAS 122654-17-5)
- Olumacostat Glasaretil (CAS 1261491-89-7)
- Gly-Neuroendocrine Regulatory Peptide-3 (human, mouse, rat) trifluoroacetate salt (CAS 1815618-19-9)
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