Nicotinamide EP Impurity C CAS 1452-77-3

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.1452-77-3
Molecular FormulaC6H6N2O
Molecular Weight122.12 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Nicotinamide EP Impurity C CAS 1452-77-3 chemical structure

Description

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a process- or degradation-related impurity, Nicotinamide EP Impurity C (CAS 1452-77-3, C6H6N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Owing to an amide group, a hydroxyl group, an ether linkage, an aromatic ring system, Nicotinamide EP Impurity C is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 122.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

As a certified reference material (CRM), Nicotinamide EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC6H6N2O
Molecular Weight122.12 g/mol
Purity>95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1957
Nitrogen Atoms2

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