n-(2-Ethylphenyl)-4-methyl-5-phenyl-2-(2-phenylacetamido)thiophene-3-carboxamide CAS 6078-91-7
| CAS No. | 6078-91-7 |
| Molecular Formula | C28H26N2O2S |
| Molecular Weight | 454.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including n-(2-Ethylphenyl)-4-methyl-5-phenyl-2-(2-phenylacetamido)thiophene-3-carboxamide.
n-(2-Ethylphenyl)-4-methyl-5-phenyl-2-(2-phenylacetamido)thiophene-3-carboxamide (CAS 6078-91-7), molecular formula C28H26N2O2S and molecular weight 454.58 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of n-(2-Ethylphenyl)-4-methyl-5-phenyl-2-(2-phenylacetamido)thiophene-3-carboxamide (C28H26N2O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), n-(2-Ethylphenyl)-4-methyl-5-phenyl-2-(2-phenylacetamido)thiophene-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H26N2O2S |
| Molecular Weight | 454.58 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related n Standards
- 3-((4-Ethylphenyl)sulfonyl)-N-(thiophen-2-ylmethyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine (CAS 892742-76-6)
- N-(2-ethylphenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 493032-82-9)
- N-(1-(4-ethylphenyl)-3-(4-(2-fluorophenyl)piperazin-1-yl)-3-oxopropyl)-2,2,2-trifluoroacetamide (CAS 866019-26-3)
- N-(4-Ethylphenyl)-2-((5-((4-methylpiperazin-1-yl)sulfonyl)pyridin-2-yl)thio)propanamide (CAS 869356-20-7)
- N-(4-Ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide (CAS 1474110-21-8)
- 1,5-Bis((4-ethylphenyl)amino)anthracene-9,10-dione (CAS 71334-59-3)
- 5-(4-Ethylphenyl)-4-(3-fluoro-4-methoxybenzoyl)-3-hydroxy-1-(pyridin-4-ylmethyl)-1H-pyrrol-2(5H)-one (CAS 609793-37-5)
- 5-(4-Ethylphenyl)-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one (CAS 488727-39-5)
Recommended Standards
- 1-(4-(1-(4-Fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4-piperidine] (CAS 147817-50-3)
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- Flurbiprofen Impurity 95 (CAS CATO-C4X-144495)
- Cilastatin Impurity 37 (CAS CATO-C4X-196037)
- 7-Cyclopropyl-1H-indole (CAS 200714-71-2)
- 4-((4-(M-tolyloxy)phenyl)sulfonamido)benzoic acid (CAS 727689-53-4)
- Sodium 2,2-difluorobutanoate (CAS 1346521-51-4)
- tert-butyl (S)-morpholine-3-carboxylate (CAS 1353085-67-2)
- 1-Phenyl-1H-pyrazole-3,5-diamine (CAS 7369-20-2)
- 4-butylmorpholine-3-carboxylic acid hydrochloride (CAS 1607020-18-7)
- (2R)-4-penten-2-ol (2R)-pent-4-en-2-ol 64584-92-5 A834817 (CAS 64584-92-5)
- (S)-tert-Butyl 4-((2-aminopropanamido)methyl)piperidine-1-carboxylate (CAS 1353992-92-3)
- Methyl 5-amino-1-methyl-1H-imidazole-2-carboxylate (CAS 1403249-02-4)
- Des-Val23-Tirzepatide (CAS CATO-CPTD788950)
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