2,5-Difluoroterephthalaldehyde CAS 608145-27-3
| CAS No. | 608145-27-3 |
| Molecular Formula | C8H4F2O2 |
| Molecular Weight | 170.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,5-Difluoroterephthalaldehyde (CAS 608145-27-3), molecular formula C8H4F2O2 and molecular weight 170.11 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2,5-Difluoroterephthalaldehyde is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 170.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2,5-Difluoroterephthalaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4F2O2 |
| Molecular Weight | 170.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
Recommended Standards
- 2-(2,4-Difluorophenyl)-2-oxoacetaldehyde (CAS 79784-36-4)
- 4,5-Difluorophthalaldehyde (CAS 854519-98-5)
- (3R,4R)-2,2-difluoro-3,4,5-trihydroxypentanal (CAS 95058-90-5)
- 4,6-Difluoro-2,3-dihydro-1-benzofuran-3-one (CAS 857062-57-8)
- 6-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid methyl ester (CAS 2122461-94-1)
- 1-[(3-hydroxyphenyl)methyl]piperidin-4-ol (CAS 90287-66-4)
- 3-Bromo-2-(difluoromethoxy)-5-isopropylbenzoic acid (CAS 2404733-62-4)
- 3-((Methyl(prop-2-yn-1-yl)amino)methyl)aniline (CAS 1556183-20-0)
- 3-(4-Fluorophenyl)-N-((5-(thiophen-2-yl)isoxazol-3-yl)methyl)-1H-pyrazole-5-carboxamide (CAS 1257800-44-4)
- N-(1,3-Benzodioxol-5-ylmethyl)-1-benzylpiperidin-4-amine (CAS 921102-89-8)
- Potassium (2,2-difluoro-1-methylcyclopropyl)trifluoroborate (CAS 2416056-34-1)
- N-(6-Fluoro-3-(2-methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)furan-2-carboxamide (CAS 864976-44-3)
- 3-(3-Boc-Aminophenyl)benzoic acid (CAS 904086-01-7)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
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