4-Chloro-6-methyl-5-(4-methylphenyl)thieno[2,3-d]pyrimidine CAS 610274-05-0
| CAS No. | 610274-05-0 |
| Molecular Formula | C14H11ClN2S |
| Molecular Weight | 274.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-Chloro-6-methyl-5-(4-methylphenyl)thieno[2,3-d]pyrimidine (C14H11ClN2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
4-Chloro-6-methyl-5-(4-methylphenyl)thieno[2,3-d]pyrimidine (CAS 610274-05-0), molecular formula C14H11ClN2S and molecular weight 274.77 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11ClN2S |
| Molecular Weight | 274.77 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 1-Benzyl-5-chloro-1H-1,3-benzodiazole-2-thiol (CAS 100440-60-6)
- 4-Chloro-2-ethyl-5-phenylthieno[2,3-d]pyrimidine (CAS 1042511-49-8)
- 2-Chloro-3-((4-methylpiperidin-1-yl)sulfonyl)pyridine (CAS 1154872-80-6)
- 2-Chloro-N-cyclohexylpyridine-3-sulfonamide (CAS 1155912-23-4)
- Ethyl 2-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-methylpropanoate (CAS 1201362-85-7)
- 2-(((5-Chloro-1,2,3-thiadiazol-4-yl)methyl)(cyclopentyl)amino)acetamide (CAS 1210126-98-9)
- 2-(1-((5-Chloro-1,2,3-thiadiazol-4-yl)methyl)piperidin-4-yl)acetamide (CAS 1222983-01-8)
- 2-Chloro-1-methanesulfonyl-1,2,3,4,5,6-hexahydro-[4,4]bipyridinyl (CAS 1316217-42-1)
Recommended Standards
- 4-Chloro-5,6-dimethyl-2-phenylthieno[2,3-d]pyrimidine (CAS 83548-60-1)
- 4-Chloro-N-methyl-5-(methylthio)-6-morpholinopyrimidin-2-amine (CAS 83199-51-3)
- 4-Chloro-5-(3,4-dimethylphenyl)thieno[2,3-d]pyrimidine (CAS 379241-56-2)
- 6-Chloro-N-cyclohexylpyridine-3-sulfonamide (CAS 622800-46-8)
- 3-(1'-Methyl-5-(trifluoromethyl)-1'h,2h-[3,4'-bipyrazol]-2-yl)propanenitrile (CAS 1006461-64-8)
- 1-Allyl-3-((3,4-dichlorophenyl)imino)indolin-2-one (CAS 338414-69-0)
- 2-(2,6-Dichlorobenzyl)-1,3-dioxolane (CAS 898759-17-6)
- ethyl (2Z)-[1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl](hydroxyimino)acetate (CAS 1006481-95-3)
- 5-Methyl-2-phenylindolizine (CAS 36944-99-7)
- 2-Chloro-N-(4-chloro-3-methylphenyl)acetamide (CAS 99585-90-7)
- Sucrose 4,6-Methyl Orthoester (CAS 116015-72-6)
- N-(5-iodopyridin-2-yl)-5-methyl-3-(pyrrolidine-1-carbonyl)isoxazole-4-carboxamide (CAS 339018-09-6)
- 5-(3-Bromopropyl)-1-ethyl-1h-1,2,4-triazole (CAS 1487785-32-9)
- Semaglutide impurity 26 (CAS CATO-C4X-222626)
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