Caffeine Monohydrate EP Impurity F CAS 611-59-6
| CAS No. | 611-59-6 |
| Molecular Formula | C7H8N4O2 |
| Molecular Weight | 180.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Caffeine Monohydrate EP Impurity F (CAS 611-59-6, C7H8N4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Caffeine Monohydrate EP Impurity F (C7H8N4O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Caffeine Monohydrate EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8N4O2 |
| Molecular Weight | 180.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 4 |
Related Caffeine Standards
Recommended Standards
- Acetaminophen Impurity 34 (CAS 146897-60-1)
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- Ramosetron Impurity 22 (CAS CATO-C4X-118222)
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- Peramivir Impurity 16 DiHCl (CAS 2641684-79-7（HCl）)
- Palbociclib Impurity 134 (CAS CATO-C4X-1125134)
- Ursodeoxycholic Acid EP Impurity E (CAS 83-44-3)
- [Pro9] Substance P (CAS 104486-69-3)
- delta-Amyrin acetate (CAS 51361-60-5)
- 6-Bromo-5-(difluoromethyl)-2-(trifluoromethyl)pyridin-3-ol (CAS 1806865-58-6)
- Ethyl (2Z)-2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-3-{[4-(trifluoromethoxy)phenyl]amino}prop-2-enoate (CAS 338966-65-7)
- 6-Chloroimidazo[1,2-a]pyrimidine-2-carboxylic acid (CAS 1020038-60-1)
- 3-Cyclopropoxy-5-ethyl-4-iodopyridine (CAS 1243404-55-8)
- (Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 299898-52-5)
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