2-(3-Bromophenyl)-4-methyl-6-(phenylamino)quinazoline-5,8-dione CAS 61416-86-2
| CAS No. | 61416-86-2 |
| Molecular Formula | C21H14BrN3O2 |
| Molecular Weight | 420.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(3-Bromophenyl)-4-methyl-6-(phenylamino)quinazoline-5,8-dione is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(3-Bromophenyl)-4-methyl-6-(phenylamino)quinazoline-5,8-dione (CAS 61416-86-2) is a high-purity analytical reference standard with the molecular formula C21H14BrN3O2 and a molecular weight of 420.26 g/mol.
The molecular framework of 2-(3-Bromophenyl)-4-methyl-6-(phenylamino)quinazoline-5,8-dione (C21H14BrN3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H14BrN3O2 |
| Molecular Weight | 420.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 2-(Benzo[d][1,3]dioxol-5-yl)-3-((4-bromophenyl)amino)-1H-inden-1-one (CAS 1023875-63-9)
- 3-((6-Bromo-4-phenylquinazolin-2-yl)amino)benzoic acid (CAS 330850-57-2)
- N'-(2,4-Dichlorobenzoyl)-1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide (CAS 302904-34-3)
- 4-[(6-Bromo-4-phenylquinazolin-2-yl)amino]benzoic acid (CAS 332102-08-6)
- 2-Methoxypropyl carbamate (CAS 13592-48-8)
- 3-(4-Methoxyphenyl)imidazo[1,2-a]pyridine (CAS 1338248-76-2)
- 4-(2,2-Dimethylpropanoyl)benzoic acid (CAS 32018-31-8)
- Acetamiprid-N-desmethyl-13C2-15N (CAS CATO-CCPD102488)
- 2-((4-Methoxyphenyl)thio)ethan-1-amine hydrochloride (CAS 79270-77-2)
- Cefoperazone EP Impurity E (Sodium salt) (CAS 40994-22-7)
- (2S)-2-(naphthalen-2-yloxy)propanoic acid (CAS 25258-16-6)
- 5-Hydroxy-4-methyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (CAS 1190316-54-1)
- 2-(Ethylamino)-2-methyl-3-(5-methyl-1h-pyrazol-1-yl)propanamide (CAS 1343619-62-4)
- (Pro30,Tyr32,Leu34)-Neuropeptide Y (28-36) (CAS 161650-01-7)
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