Calcitriol Impurity 7 CAS 61476-45-7
| CAS No. | 61476-45-7 |
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Calcitriol Impurity 7 is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Calcitriol Impurity 7 (CAS 61476-45-7, C27H44O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Calcitriol Impurity 7 (C27H44O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
Related Calcitriol Standards
- Calcitriol (CAS 32222-06-3)
- Calcitriol Impurity 25 (CAS 134523-84-5)
- Calcitriol Impurity 26 (CAS 57102-09-7)
- Calcitriol Impurity 27 (CAS CATO-C4X-151027)
- Calcitriol Impurity 29 (CAS 96614-28-7)
- Calcitriol Impurity 31 (CAS 96862-25-8)
- Calcitriol impurity 37 (CAS CATO-C4X-151037)
- Calcitriol Impurity 38 (CAS CATO-C4X-151038)
Recommended Standards
- Calcitriol Impurity 62 (CAS CATO-C4X-151062)
- 25, 26-Dihydroxy Vitamin D3 (CAS 29261-12-9)
- Calcitriol Impurity 6 (CAS CATO-C4X-15106)
- Cholecalciferol impurity 22 (CAS CATO-C4X-158622)
- Linezolid Impurity 77 (CAS 3920-11-4)
- Furosemide Impurity 50 (CAS CATO-C4X-140250)
- Ilaprazole impurity 196 (CAS CATO-C4X-1130196)
- Triptolide Impurity 1 (CAS 1254702-87-8)
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