Melphalan EP Impurity D CAS 61733-01-5
| CAS No. | 61733-01-5 |
| Molecular Formula | C13H19ClN2O3 |
| Molecular Weight | 286.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Melphalan EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Melphalan EP Impurity D (CAS 61733-01-5, C13H19ClN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Melphalan EP Impurity D is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 286.75 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H19ClN2O3 |
| Molecular Weight | 286.75 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Melphalan Standards
Recommended Standards
- Procaine Impurity 7 (CAS 855198-14-0)
- 2-(5-Amino-2-chlorophenyl)-N,N-dimethyl-1H-benzo[d]imidazol-5-amine (CAS 1079264-85-9)
- Procaine Impurity 5 (CAS CATO-C4X-26235)
- 6-amino-1-[(4-chlorophenyl)methyl]-1,2,3,4-tetrahydroquinolin-2-one (CAS 1153515-25-3)
- Dronedarone Impurity 72 Mesylate (CAS CATO-C4X-109272)
- Lefamulinum Impurity 19 (CAS CATO-C4X-304719)
- Tedizolid Impurity 16 (CAS 1700656-54-7)
- 3,4-dihydro-Pyrido[2,1-c][1,2,4]thiadiazine-9-carboxylic acid-2,2-dioxide (CAS 565165-53-9)
- 5-Bromo-2,6-dimethyl-2H-indazole (CAS 1159511-90-6)
- 2-Methyl-4-(propylamino)quinolin-8-ol (CAS 805965-40-6)
- 1-Chloroethyl methyl ether (CAS 1538-87-0)
- (R)-(-)-Metalaxyl-d6 (CAS 1398112-32-7)
- 2-((2-Chlorobenzyl)amino)butan-1-ol (CAS 893583-48-7)
- Semaglutide Impurity 139 (CAS CATO-C4X-2226139)
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