4-(4-Chlorobenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(thiophen-2-yl)-1H-pyrrol-2(5H)-one CAS 618074-50-3
| CAS No. | 618074-50-3 |
| Molecular Formula | C20H14ClNO4S |
| Molecular Weight | 399.85 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(4-Chlorobenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(thiophen-2-yl)-1H-pyrrol-2(5H)-one (CAS 618074-50-3) is a high-purity analytical reference standard with the molecular formula C20H14ClNO4S and a molecular weight of 399.85 g/mol.
4-(4-Chlorobenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(thiophen-2-yl)-1H-pyrrol-2(5H)-one (C20H14ClNO4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H14ClNO4S |
| Molecular Weight | 399.85 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chlorobenzoyl Standards
- (E)-({4-[4-(3-chlorobenzoyl)piperazin-1-yl]-3-nitrophenyl}methylidene)(methoxy)amine (CAS 383147-23-7)
- 3-[1-(3-Chlorobenzoyl)piperidin-4-yl]-4-(4-methylphenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775357-62-4)
- 1-(4-Chlorobenzoyl)-4-{[(4-chlorophenyl)sulfanyl]methyl}piperidin-4-ol (CAS 478248-10-1)
- Methyl 3-[1-(4-chlorobenzoyl)-3-methyl-1H-pyrazole-4-amido]thiophene-2-carboxylate (CAS 321574-10-1)
- 5-(4-Chlorobenzoyl)-2-(phenylamino)-4-(1H-pyrrol-1-yl)thiophene-3-carbonitrile (CAS 338401-16-4)
- 5-(4-(4-Chlorobenzoyl)piperazin-1-yl)-6-phenylpyridazin-3(2H)-one (CAS 477863-44-8)
- Ethyl 3-(4-chlorobenzoyl)-5-(pyridin-2-yl)indolizine-1-carboxylate (CAS 252986-68-8)
- 6-(4-Chlorobenzoyl)-4-(3-chlorophenyl)quinolin-2(1H)-one (CAS 192187-32-9)
Recommended Standards
- 4-((5-((4-Chlorophenyl)sulfonyl)furan-2-yl)imino)-2-methylbutan-2-yl hydrazinecarboxylate (CAS 75745-76-5)
- Methyl 2-amino-4-(2-chlorophenyl)-5-oxo-4H,5H-thiochromeno[4,3-b]pyran-3-carboxylate (CAS 939894-13-0)
- 3-Nitro-4-(phenylthio)benzyl 4-chlorobenzoate (CAS 320424-13-3)
- N'-((5-(4-Chlorobenzyl)-6-oxo-2-thioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylene)isonicotinohydrazide (CAS 31349-14-1)
- 5-Hydroxy-2-methyl-2,3-dihydro-1h-isoindol-1-one (CAS 109803-65-8)
- 4-Cyano-2-fluoro-N-((3-hydroxy-4-(5-methylbenzo[d]oxazol-2-yl)phenyl)carbamothioyl)benzamide (CAS 593238-87-0)
- (R)-2-(Hydrazinecarbonyl)pyrrolidine-2-carboxylic acid (CAS 141873-57-6)
- (4,6-Dimethoxypyrimidin-2-yl)boronic acid (CAS 1374450-52-8)
- Hydrochlorothiazide-13C6 (CAS 1261396-79-5)
- 5-Amino-2-nitrobenzonitrile (CAS 72115-08-3)
- 1-(3-Aminophenyl)-N,N-dimethylmethanesulfonamide (CAS 774461-97-1)
- 2-(Isopropyl(1-(thiazol-2-yl)ethyl)amino)acetic acid (CAS 1353947-25-7)
- 4-Chloroisoquinolin-7-amine (CAS 1936362-61-6)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
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