4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one CAS 618074-75-2
| CAS No. | 618074-75-2 |
| Molecular Formula | C25H21FN2O5 |
| Molecular Weight | 448.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one (CAS 618074-75-2), molecular formula C25H21FN2O5 and molecular weight 448.44 g/mol, is a CATO reference standard with documented purity and traceability.
4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one (C25H21FN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C25H21FN2O5 |
| Molecular Weight | 448.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
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- 4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-(4-nitrophenyl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one (CAS 618073-84-0)
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Recommended Standards
- (S)-2,6-Diamino-N-(4-(5-amino-6,8-difluoro-7-methyl-4-oxo-4H-chromen-2-yl)-2-fluorophenyl)hexanamide (CAS 468719-52-0)
- Curcumin Sulfate (CAS 339286-19-0)
- (1-(tert-butoxycarbonyl)-5-(((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)methyl)-1H-indol-2-yl)boronic acid (CAS 913388-73-5)
- Tanzisertib (CAS 899805-25-5)
- 1-(2-Bromo-4-fluorobenzyl)cyclopropan-1-amine (CAS 1483373-80-3)
- 6-Phenylfuro[2,3-d]pyrimidin-2(1H)-one (CAS 896450-66-1)
- 1,3-Bis(tert-butylamino)propan-2-ol (CAS 15046-09-0)
- Pyridoxine Tripalmitate (CAS 4372-46-7)
- 2,6-Dimethyl-4-nitrobenzene-1-sulfonyl chloride (CAS 64835-40-1)
- 2-(4-Chlorophenyl)-7-fluoro-4-(4-fluorophenyl)phthalazin-1(2H)-one (CAS 161716-20-7)
- 4-(5-Nonylpyrimidin-2-yl)benzoic acid (CAS 128005-60-7)
- Methyl 7-Methylindole-2-carboxylate (CAS 16732-82-4)
- 6-Fluoro-7-methyl-1H-indole-2-carboxylic acid (CAS 883531-61-1)
- Ginseng Tetrapeptide (CAS 178553-95-2)
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