2-Hydroxy-6-methoxynaphthalene-1,4-dione CAS 6223-31-0

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Hydroxy-6-methoxynaphthalene-1,4-dione.

2-Hydroxy-6-methoxynaphthalene-1,4-dione (CAS 6223-31-0), molecular formula C11H8O4 and molecular weight 204.18 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-Hydroxy-6-methoxynaphthalene-1,4-dione (C11H8O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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