4,6-Dichloro-2-ethylpyrimidin-5-amine CAS 6237-96-3
| CAS No. | 6237-96-3 |
| Molecular Formula | C6H7Cl2N3 |
| Molecular Weight | 192.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4,6-Dichloro-2-ethylpyrimidin-5-amine.
4,6-Dichloro-2-ethylpyrimidin-5-amine (CAS 6237-96-3) is a high-purity analytical reference standard with the molecular formula C6H7Cl2N3 and a molecular weight of 192.05 g/mol.
Owing to a nitrile group, chlorine substitution, an aromatic ring system, 4,6-Dichloro-2-ethylpyrimidin-5-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 192.05 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H7Cl2N3 |
| Molecular Weight | 192.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Dichloro Standards
- 4,6-Dichloro-N-ethylpyrimidin-2-amine (CAS 10371-48-9)
- 2,6-Dichloro-N,N-dimethylpyrimidin-4-amine (CAS 117077-93-7)
- 5,6-Dichloro-N,N-dimethylpyridazin-4-amine (CAS 17258-34-3)
- 3,5-Dichloro-N,N-dimethylpyrazin-2-amine (CAS 1935333-43-9)
- 5,6-Dichloro-N,N-dimethylpyrazin-2-amine (CAS 1936121-46-8)
- 2,4-Dichloro-6-isopropyl-1,3,5-triazine (CAS 30894-74-7)
- 2,4-Dichloro-N,N-dimethylpyrimidin-5-amine (CAS 5298-50-0)
- 2,6-dichloro-4-N-methylpyridine-3,4-diamine (CAS 914942-86-2)
Recommended Standards
- 4-(bromomethyl)-4-methylpyrrolidin-2-one (CAS 2044773-40-0)
- 4,6-Dichloro-N,N-dimethylpyrimidin-2-amine (CAS 5734-68-9)
- 3-bromoazepan-2-one (CAS 3457-66-7)
- 4,6-Dichloro-N-ethylpyrimidin-5-amine (CAS 885500-42-5)
- Tert-butyl 1-formylcyclopentane-1-carboxylate (CAS 1546151-07-8)
- (2S,3R)-2-Hydroxy-3-methyl-butanedioic Acid Dimethyl Ester (CAS 73890-17-2)
- Ethyl 3-(pyridin-3-yl)benzoate (CAS 4385-73-3)
- Ethyl 2-benzyl-3-ethoxy-2-fluoro-3-iminopropanoate (CAS 18283-08-4)
- 5,5'-(Pyrazine-2,6-diyl)diisophthalicacid (CAS 2757730-24-6)
- 1,2-Bis[(2R,5R)-2,5-dimethylphospholano]benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate (CAS 187682-63-9)
- 1,1-Dimethyl-3-oxo-1,3-dihydro-2-benzofuran-5-carboxylic acid (CAS 1428-81-5)
- Methylergonovine Maleate (CAS 57432-61-8)
- 1-Amino-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (CAS 72567-46-5)
- Insulin Degludec Impurity 1 (CAS 843666-26-2)
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