Methyl 2-chloro-4-(methylsulfonyl)benzoate CAS 623927-88-8
| CAS No. | 623927-88-8 |
| Molecular Formula | C9H9ClO4S |
| Molecular Weight | 248.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Methyl 2-chloro-4-(methylsulfonyl)benzoate (CAS 623927-88-8), molecular formula C9H9ClO4S and molecular weight 248.68 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 2-chloro-4-(methylsulfonyl)benzoate (C9H9ClO4S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9ClO4S |
| Molecular Weight | 248.68 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Methyl Standards
- 2-Chloro-3-methyl-4-(methylsulfonyl)benzoic acid (CAS 106904-09-0)
- 2-(3-Chloro-4-(methylsulfonyl)phenyl)acetic acid (CAS 1265819-83-7)
- 4-Chloro-2-cyclopropyl-6-(4-fluorophenyl)pyrimidine (CAS 1354753-95-9)
- 5-chloro-2-(ethanesulfonyl)benzoic acid (CAS 1384428-08-3)
- Methyl 2-chloro-5-(methylsulfonyl)benzoate (CAS 151104-30-2)
- Methyl 3-chloro-5-(methylsulfonyl)benzoate (CAS 151104-62-0)
- 4-Chloro-2-methyl-5-(methylsulfonyl)-benzoic Acid (CAS 176309-00-5)
- 1-(3-Chloro-4-fluorophenyl)-2-phenylethan-1-one (CAS 845781-19-3)
Recommended Standards
- Methyl 2-[4-(chlorosulfonyl)phenyl]acetate (CAS 53305-12-7)
- Methyl 3-(Chlorosulfonyl)-2-methylbenzoate (CAS 98812-46-5)
- Methyl 2-(3-chlorophenyl)sulfonylacetate (CAS 78066-30-5)
- Methyl 4-(chlorosulfonyl)-3-methylbenzoate (CAS 260968-81-8)
- (+/-)-2-Acetylaminobutanoic Acid-d3 (CAS 1219397-36-0)
- 2,4,6-tris(4-methoxyphenyl)pyrylium tetrafluoroborate 580-34-7 (CAS 580-34-7)
- 4-Methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid (CAS 1081129-70-5)
- (5-Iodopent-1-en-1-yl)boronic acid (CAS 85976-78-9)
- 1-(Cyclopentylmethyl)-4-phenylquinazolin-2(1H)-one (CAS 1956309-32-2)
- 4-Bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylic acid (CAS 1856071-67-4)
- (11bS)-4-Hydroxy-2,6-bis([1,1':3',1''-terphenyl]-5'-yl)-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin (CAS 1496637-05-8)
- Ethyl 5-sulfamoylfuran-3-carboxylate (CAS 256373-94-1)
- 1-(3,4-Dichlorophenyl)cyclopropanecarboxylic Acid (CAS 342386-78-1)
- Semaglutide Impurity 115 (CAS CATO-C4X-2226115)
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