Glyceryl Trinitrate Solution EP Impurity B CAS 624-43-1
| CAS No. | 624-43-1 |
| Molecular Formula | C3H7NO5 |
| Molecular Weight | 137.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Glyceryl Trinitrate Solution EP Impurity B (CAS 624-43-1, C3H7NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Glyceryl Trinitrate Solution EP Impurity B (C3H7NO5) contains an amino-acid-derived structure, an amide group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C3H7NO5 |
| Molecular Weight | 137.09 g/mol |
| Purity | 1.0 mg/mL in Acetonitrile |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Glyceryl Standards
- Glyceryl Trinitrate Solution EP Impurity C (CAS 620-12-2)
- Glyceryl Trinitrate Impurity 6 (CAS 1433993-67-9)
- Glyceryl Trinitrate Solution EP Impurity D (CAS 621-65-8)
- Glyceryl Trinitrate Solution EP Impurity E (CAS 623-87-0)
- α-Glyceryl Anthranilate (CAS 71574-35-1)
- Glyceryl Valproate Impurity 1 (CAS 77656-37-2)
- Glyceryl Trinitrate Impurity 8 (CAS CATO-C4X-22318)
- Glyceryl Monocaprate (CAS 2277-23-8)
Recommended Standards
- 5-Ethynylisoxazole-3-carboxylic acid (CAS 89488-59-5)
- 5-Cyano-2-furancarboxylic Acid (CAS 212197-74-5)
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- 3-Furancarboxylic acid, 2-cyano- (CAS 861372-94-3)
- Cenobamate Impurity 46 (CAS CATO-C4X-241646)
- Enarodustat Impurity 4 (CAS CATO-C4X-32284)
- Ruxolitinib Impurity 35 (CAS CATO-C4X-205835)
- Methyl 3-(4-aminophenoxy)benzoate (CAS 192768-24-4)
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- 3-Chloro-6-fluoro-2-methylimidazo[1,2-a]pyridine (CAS 1934817-54-5)
- 1-(4-Acetyl-phenyl)-piperidine-4-carboxylic acid amide (CAS 250713-72-5)
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- Methyl 3-amino-5-methylisonicotinate (CAS 1805106-63-1)
- Semaglutide impurity 210 (CAS CATO-C4X-2226210)
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