Ceftazidime EP Impurity F(HCl) CAS 628-13-7
| CAS No. | 628-13-7 |
| Molecular Formula | C5H5N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 115.56 g/mol gives Ceftazidime EP Impurity F(HCl) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ceftazidime EP Impurity F(HCl) (CAS 628-13-7, C5H5NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrile group, chlorine substitution, Ceftazidime EP Impurity F(HCl) is typically white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 115.56 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5N HCl |
| Molecular Weight | 115.56 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ceftazidime Standards
- Ceftazidime EP Impurity A (CAS 1000980-60-8)
- Ceftazidime Pentahydrate - Impurity C (Iodide Salt) (CAS 100988-63-4)
- Ceftazidime EP Impurity E (CAS 102772-66-7)
- Ceftazidime Hydrate (CAS 120618-65-7)
- Ceftazidime Impurity 13 (CAS 1301254-50-1)
- Ceftazidime Impurity 46 (CAS 134203-50-2)
- Ceftazidime EP Impurity H (CAS 1354396-23-8)
- Ceftazidime Impurity 23 (CAS 158183-05-2)
Recommended Standards
- Lenalidomide Impurity 51 (CAS 1063995-41-4)
- Gadoxetate impurity 29 (CAS CATO-C4X-261829)
- Fenofibrate Impurity 21 (CAS CATO-C4X-101821)
- 5-Dimethylaminomethyl-4-p-tolyl-thiazol-2-ylamine (CAS 870693-07-5)
- 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (CAS 61563-24-4)
- Methyl 5-methyl-3-(prop-2-yn-1-yloxy)thiophene-2-carboxylate (CAS 1774902-38-3)
- N-Hydroxy-4-(naphthalen-1-yl)benzamide (CAS 106359-61-9)
- (1S,4S)-4-methoxycyclopent-2-en-1-ol (CAS 1932182-36-9)
- Benzyl stearate (CAS 5531-65-7)
- Acetyl Tripeptide-1 (CAS 350595-76-5)
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