Thiamine nitrate EP Impurity F CAS 6309-04-2
| CAS No. | 6309-04-2 |
| Molecular Formula | C13H19N4OS |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Thiamine nitrate EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Thiamine nitrate EP Impurity F (CAS 6309-04-2, C13H19N4OSHBrBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, bromine substitution, Thiamine nitrate EP Impurity F is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 440.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H19N4OS HBr Br |
| Molecular Weight | 440.20 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Thiamine Standards
- Thiamine Impurity 30 (CAS 100502-51-0)
- Thiamine Nitrate EP Impurity G (CAS 1037-29-2)
- Thiamine Impurity 11 (CAS 105070-51-7)
- Thiamine /Vitamin B1 Impurity 50 (CAS 10553-88-5)
- Thiamine /Vitamin B1 Impurity 54 Ammonium Salt (CAS 10553-88-5 (free form))
- Thiamine EP Impurity F (CAS 10593-44-9)
- Thiamine disulfide (dinitrate) (CAS 109125-52-2)
- Thiamine Impurity 54 (CAS 1124-01-2)
Recommended Standards
- Fosfomycin Impurity 26 (CAS CATO-C4X-131626)
- Baricitinib Impurity 32 (CAS 269410-08-4)
- Bisoprolol Impurity 81 (CAS 2775292-22-1)
- 5-Methoxy-N-methylpyrimidin-4-amine (CAS 1447967-24-9)
- tert-Butyl isoindolin-2-ylcarbamate (CAS 131762-67-9)
- (2S,3R)-2-methyl-3-(methylsulfonylmethyl)azetidine;hydrochloride (CAS 2411592-27-1)
- 5-(Dimethylphosphoryl)furan-2-carboxylic acid (CAS 2361984-11-2)
- α,α-Dimethyl-2-oxo-1-pyrrolidineacetic acid methyl ester (CAS 664305-21-9)
- tert-Butyl N-[(1R)-1-(2-bromo-4-fluorophenyl)ethyl]carbamate (CAS 1086600-20-5)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
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