N-[4-(5-Chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-3-methylphenyl]-4-(trifluoromethyl)benzamide CAS 633318-76-0
| CAS No. | 633318-76-0 |
| Molecular Formula | C23H14ClF3N2O3 |
| Molecular Weight | 458.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-[4-(5-Chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-3-methylphenyl]-4-(trifluoromethyl)benzamide.
N-[4-(5-Chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-3-methylphenyl]-4-(trifluoromethyl)benzamide (CAS 633318-76-0), molecular formula C23H14ClF3N2O3 and molecular weight 458.82 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, N-[4-(5-Chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-3-methylphenyl]-4-(trifluoromethyl)benzamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 458.82 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-[4-(5-Chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-3-methylphenyl]-4-(trifluoromethyl)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H14ClF3N2O3 |
| Molecular Weight | 458.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
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- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-N-(4-methoxyphenyl)benzene-1-sulfonamide (CAS 338775-28-3)
- 5-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-3-yl}-3-(4-fluorophenyl)-2,1-benzoxazole (CAS 321571-05-5)
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- 3-[2-Chloro-4-(4-chlorophenoxy)phenyl]-N-(4-chlorophenyl)-1H-pyrazole-1-carboxamide (CAS 321522-25-2)
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Recommended Standards
- 5-(4-Chlorobenzoyl)-6-(3-ethoxy-4-hydroxyphenyl)-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one (CAS 474005-43-1)
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- 5-(4-Chlorobenzoyl)-6-(3,4-dimethoxyphenyl)-4-hydroxy-4-(trifluoromethyl)tetrahydropyrimidin-2(1H)-one (CAS 623936-46-9)
- Fluoxastrobin (CAS 361377-29-9)
- 2-Trifluoromethanesulfonylbenzene-1-thiol (CAS 1156000-34-8)
- Methyl (E)-2-(2,3-dichlorobenzylidene)hydrazine-1-carboxylate (CAS 356101-82-1)
- Tert-butyl 2-methyl-3,4-dihydropyridine-1(2H)-carboxylate (CAS 1257080-98-0)
- 2,4,5-Tribromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazole (CAS 159590-01-9)
- 2-Ethyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine (CAS 1315059-97-2)
- 2-[Bis(methylsulfanyl)methylidene]-2,3-dihydro-1H-indene-1,3-dione (CAS 65472-87-9)
- 1-Benzhydryl-3-(4-fluorophenylthio)azetidine (CAS 942473-76-9)
- 7-Chloro-1-(propylamino)anthracene-9,10-dione (CAS 61100-57-0)
- (1,3-Thiazol-5-yl)methyl N-(3,4-dichlorophenyl)carbamate (CAS 338981-80-9)
- His-Cyclic-Semaglutide (CAS CATO-C4X-2226182)
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