Dopamine Impurity 45 CAS 637-26-3
| CAS No. | 637-26-3 |
| Molecular Formula | C10H15NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dopamine Impurity 45 is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Dopamine Impurity 45 (CAS 637-26-3), a pharmacopoeial impurity reference standard (molecular formula C10H15NO2HCl, MW 217.69 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Dopamine Impurity 45 (C10H15NO2HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dopamine Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H15NO2 HCl |
| Molecular Weight | 217.69 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dopamine Standards
Recommended Standards
- Mirogabalin Impurity 83 (CAS CATO-C4X-292483)
- Pramipexole Impurity 40 (CAS 1867177-06-7)
- Edoxaban Impurity 116 (CAS 2089454-69-1)
- (1,5-Dimethyl-1H-1,2,4-triazol-3-yl)methanol (CAS 1034197-36-8)
- 5-Bromo-N-(2-oxoazepan-3-yl)thiophene-3-carboxamide (CAS 1214114-60-9)
- Flavin Adenine Dinucleotide Disodium Salt Hydrate (CAS 1261238-16-7)
- 5-Formyl-2,3-dimethoxybenzoic acid (CAS 27203-73-2)
- 3'-(P-tolyl)spiro[indene-2,2'-oxiran]-1(3H)-one (CAS 54763-67-6)
- 2-Iodothiophene-3-carbonitrile (CAS 18800-01-6)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com