6-Chloro-1H-pyrazolo[3,4-b]pyridine CAS 63725-51-9
| CAS No. | 63725-51-9 |
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
6-Chloro-1H-pyrazolo[3,4-b]pyridine (CAS 63725-51-9), molecular formula C6H4ClN3 and molecular weight 153.57 g/mol, is a CATO reference standard with documented purity and traceability.
6-Chloro-1H-pyrazolo[3,4-b]pyridine (C6H4ClN3) contains a nitrile group, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS 1041864-02-1)
- 2-Chloro-1H-imidazo[4,5-b]pyridine (CAS 104685-82-7)
- 6-Chloro-[1,2,4]triazolo[4,3-a]pyridine (CAS 1048913-70-7)
- 3-chloro-[1,2,3]triazolo[1,5-a]pyridine (CAS 1087206-32-3)
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine (CAS 1111638-10-8)
- 2-Chloro-5H-pyrrolo[3,2-d]pyrimidine (CAS 1119280-66-8)
- 1-Chloro-4-cyanatobenzene (CAS 1124-59-0)
- 5-Chloro-4-methylpyrimidine-2-carbonitrile (CAS 114969-79-8)
Recommended Standards
- 6-Chloro-1H-imidazo[4,5-c]pyridine (CAS 2589-11-9)
- 6-Chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS 90994-17-5)
- 6-Chloro-1H-imidazo[4,5-b]pyridine (CAS 21422-66-2)
- 6-Chlorobenzo[d]isoxazole (CAS 39835-07-9)
- 2-bromo-1-(oxolan-2-yl)ethan-1-one (CAS 141061-17-8)
- N-{4-[(4-bromophenyl)sulfanyl]phenyl}-4-fluorobenzamide (CAS 339104-54-0)
- 1-Methyl-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (CAS 26516-28-9)
- 1-Methyl-5-{[(pyridin-3-yl)methyl]amino}-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile (CAS 318517-86-1)
- 8-Chloro-6-pentadecylimidazo[1,5-a]pyrimidin-2(1H)-one (CAS 143915-64-4)
- (R,R,S,S)-Orlistat (CAS 1225451-00-2)
- 6-Chloro-3-methylquinoxalin-5-amine (CAS 919994-76-6)
- (1-Methyl-5-phenyl-1H-pyrazol-4-yl)boronic acid (CAS 1858252-28-4)
- 3-(2-Bromo-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)piperidine-2,6-dione (CAS 2229724-66-5)
- Osteogenic Growth Peptide (10-14) (CAS 105250-85-9)
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