Anagrelide Impurity 3 CAS 6379-46-0
| CAS No. | 6379-46-0 |
| Molecular Formula | C6HCl3N2O4 |
| Molecular Weight | 271.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Anagrelide Impurity 3 (C6HCl3N2O4) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 271.44 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Anagrelide Impurity 3 (CAS 6379-46-0, C6HCl3N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6HCl3N2O4 |
| Molecular Weight | 271.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Anagrelide Standards
- Anagrelide Impurity 45 (CAS CATO-C4X-224045)
- Anagrelide Impurity 12 (CAS 1159977-03-3)
- Anagrelide USP Related Compound A (CAS 70406-92-7)
- Anagrelide-13C3 (CAS 1219531-58-4)
- Anagrelide (CAS 68475-42-3)
- Anagrelide Impurity 32 (CAS 70380-52-8)
- Anagrelide impurity 25 (CAS 1092352-99-2)
- Anagrelide Impurity 6 (CAS 349150-82-9)
Recommended Standards
- 2-(Dodecyldimethylammonio)acetate (CAS 683-10-3)
- 2-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-1,3-thiazole-5-carbaldehyde (CAS 1803608-22-1)
- 66455-29-6 Empigen BB Betaines, C12-14-alkyldimethyl EINECS 266-368-1 (CAS 66455-29-6)
- 2-Chloro-4-fluoro-6-iodoaniline (CAS 1005196-28-0)
- Urapidil Impurity 47 (CAS CATO-C4X-192447)
- Promethazine Impurity 8 (CAS CATO-C4X-14188)
- Sulpiride EP Impurity G (CAS 67381-52-6)
- (4'-Ethyl-3-fluoro-[1,1'-biphenyl]-4-yl)boronic acid (CAS 900796-46-5)
- 3-(Methoxycarbonyl)-5-oxo-5H-thiazolo[3,2-a]pyridine-8-carboxylic acid (CAS 2387596-63-4)
- (2,6-Dichloropyridin-4-yl)methanamine hydrochloride (CAS 879660-72-7)
- 2-((1H-Indol-7-yl)oxy)ethan-1-ol (CAS 313656-45-0)
- (1S,5S,6S)-tert-Butyl 5-bromo-8-oxo-7-oxa-3-azabicyclo[4.2.0]octane-3-carboxylate (CAS 319911-72-3)
- 2-Amino-5-cyano-1-methyl-1H-imidazole-4-carbonyl chloride (CAS 741225-68-3)
- Peptide 439 (CAS CATO-CPTD788439)
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