Probucol Related Compound B CAS 6386-58-9
| CAS No. | 6386-58-9 |
| Molecular Formula | C28H42O2S2 |
| Molecular Weight | 474.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Probucol Related Compound B (C28H42O2S2) is characterized by a steroid core, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Probucol Related Compound B (CAS 6386-58-9, C28H42O2S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H42O2S2 |
| Molecular Weight | 474.76 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Sulfur Atoms | 2 |
Related Probucol Standards
- Probucol Impurity 16 (CAS 2093160-06-4)
- Probucol Impurity 11 (CAS 4673-51-2)
- Probucol Impurity 7 (CAS 6386-61-4)
- Probucol Impurity 15 (CAS 123500-67-4)
- Probucol (CAS 23288-49-5)
- Probucol Related Compound C (CAS 1391054-68-4)
- Probucol-d6 (CAS 23288-49-5 (unlabelled))
- Probucol-propionyl-<SUP>13</SUP>C<SUB>3</SUB> (CAS 1173019-29-8)
Recommended Standards
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- 1-Methoxy-1-oxopropan-2-yl 3-(pyrrolidin-3-yl)propanoate (CAS 850237-69-3)
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- 1-Ethyl-3-methyl-4-nitro-1h-pyrazole (CAS 1001500-32-8)
- 8-Methyl-4-(2-phenylacetyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326814-84-9)
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