Upadacitinib Impurity 20 CAS CATO-C4X-240520
| CAS No. | CATO-C4X-240520 |
| Molecular Formula | C17H19F3N6O |
| Molecular Weight | 380.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Upadacitinib Impurity 20 (CAS CATO-C4X-240520, C17H19F3N6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Upadacitinib Impurity 20 (C17H19F3N6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H19F3N6O |
| Molecular Weight | 380.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Upadacitinib Standards
- Upadacitinib (CAS 1310726-60-3)
- Upadacitinib Impurity 144 (CAS CATO-C4X-2405144)
- Upadacitinib Impurity 22 (CAS CATO-C4X-240522)
- Upadacitinib Impurity 26 (CAS CATO-C4X-240526)
- Upadacitinib Impurity 28 (CAS 1310726-59-0)
- Upadacitinib-15N-d2 (CAS CATO-C4X-240579)
- Upadacitinib Impurity 128 (CAS CATO-C4X-2405128)
- Upadacitinib Impurity 72 (CAS CATO-C4X-240572)
Recommended Standards
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